UniProt Accession

 MARH8_MOUSE; Q9DBD2 

Genbank Protein ID

 AK005032; AK154976; BC050908; BC053090 

Genbank Nucleotide ID

 BAB23759.1; BAE32966.1; AAH50908.1; AAH53090.1 

Protein Name

 E3 ubiquitin-protein ligase MARCH8 

Protein Synonyms/Alias

 Cellular modulator of immune recognition; c-MIR; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; MARCH-VIII 

Gene Name

 March8 

Gene Synonyms/Alias

 Mir 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
248	SKKNIFEKSALTEPT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS (By similarity). 

Sequence Annotation

 ZN_FING 68 129 RING-CH-type.  

Keyword

 Adaptive immunity; Complete proteome; Cytoplasmic vesicle; Endosome; Immunity; Ligase; Lysosome; Membrane; Metal-binding; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 286 AA 

Protein Sequence

Gene Ontology

 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; ISS:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0002495; P:antigen processing and presentation of peptide antigen via MHC class II; IDA:UniProtKB.
 GO:0045347; P:negative regulation of MHC class II biosynthetic process; IDA:BHF-UCL.
 GO:0000209; P:protein polyubiquitination; IEA:Compara. 

Interpro

 IPR011016; Znf_RING-CH.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF12906; RINGv 

SMART

 SM00744; RINGv 

PROSITE

 PS51292; ZF_RING_CH 

PRINTS