UniProt Accession

 GFRP_RAT; P70552 

Genbank Protein ID

 U53710; U85512; BC086944 

Genbank Nucleotide ID

 AAC52776.1; AAD09241.1; AAH86944.1 

Protein Name

 GTP cyclohydrolase 1 feedback regulatory protein 

Protein Synonyms/Alias

 GFRP; GTP cyclohydrolase I feedback regulatory protein; p35 

Gene Name

 Gchfr 

Gene Synonyms/Alias

 Gfrp 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
36	MQQLGASKRRVLGNN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 84 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0042470; C:melanosome; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0016597; F:amino acid binding; IDA:RGD.
 GO:0004857; F:enzyme inhibitor activity; IDA:RGD.
 GO:0044549; F:GTP cyclohydrolase binding; IDA:RGD.
 GO:0009890; P:negative regulation of biosynthetic process; IEA:InterPro.
 GO:0043105; P:negative regulation of GTP cyclohydrolase I activity; IDA:RGD.
 GO:0051291; P:protein heterooligomerization; IDA:RGD.
 GO:0045428; P:regulation of nitric oxide biosynthetic process; NAS:RGD. 

Interpro

 IPR009112; GTP_CycHdrlase_I_reg. 

Pfam

 PF06399; GFRP 

SMART

  

PROSITE

  

PRINTS