CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044710
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase Yes 
Protein Synonyms/Alias
  
Gene Name
 YES1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20ENKSPAIKYRPENTPubiquitination[1]
240AQFDTLQKLVKHYTEubiquitination[2]
442QGAKFPIKWTAPEAAubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 548 AA 
Protein Sequence
MLDLIMGCIK SKENKSPAIK YRPENTPEPV STSVSHYGAE PTTVSPCPSS SAKGTAVNFS 60
SLSMTPFGGS SGVTPFGGAS SSFSVVPSSY PAGLTGGVTI FVALYDYEAR TTEDLSFKKG 120
ERFQIINNTE GDWWEARSIA TGKNGYIPSN YVAPADSIQA EEWYFGKMGR KDAERLLLNP 180
GNQRGIFLVR ESETTKGAYS LSIRDWDEIR GDNVKHYKIR KLDNGGYYIT TRAQFDTLQK 240
LVKHYTEHAD GLCHKLTTVC PTVKPQTQGL AKDAWEIPRE SLRLEVKLGQ GCFGEVWMGT 300
WNGTTKVAIK TLKPGTMMPE AFLQEAQIMK KLRHDKLVPL YAVVSEEPIY IVTEFMSKGS 360
LLDFLKEGDG KYLKLPQLVD MAAQIADGMA YIERMNYIHR DLRAANILVG ENLVCKIADF 420
GLARLIEDNE YTARQGAKFP IKWTAPEAAL YGRFTIKSDV WSFGILQTEL VTKGRVPYPG 480
MVNREVLEQV ERGYRMPCPQ GCPESLHELM NLCWKKDPDE RPTFEYIQSF LEDYFTATEP 540
QYQPGENL 548 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR000980; SH2.
 IPR001452; SH3_domain.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF07714; Pkinase_Tyr
 PF00017; SH2
 PF00018; SH3_1 
SMART
 SM00252; SH2
 SM00326; SH3
 SM00219; TyrKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS50001; SH2
 PS50002; SH3 
PRINTS
 PR00401; SH2DOMAIN.
 PR00452; SH3DOMAIN.
 PR00109; TYRKINASE.