UniProt Accession

 B3KUN1_HUMAN; B3KUN1 

Genbank Protein ID

 AK097599; AB451240; AB451365; CH471062; CH471062 

Genbank Nucleotide ID

 BAG53493.1; BAG70054.1; BAG70179.1; EAW62268.1; EAW62269.1 

Protein Name

 Serine/threonine-protein phosphatase 

Protein Synonyms/Alias

  

Gene Name

 PPP2CA 

Gene Synonyms/Alias

 hCG_16586 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MDEKVFTKELD	ubiquitination	[1]
8	MDEKVFTKELDQWIE	ubiquitination	[2]
21	IEQLNECKQLSESQV	ubiquitination	[2]
29	QLSESQVKSLCEKAK	ubiquitination	[2]
41	KAKEILTKESNVQEV	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Hydrolase; Iron. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:Compara.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0007498; P:mesoderm development; IEA:Compara.
 GO:0006470; P:protein dephosphorylation; IEA:Compara.
 GO:0070208; P:protein heterotrimerization; IEA:Compara.
 GO:0031952; P:regulation of protein autophosphorylation; IEA:Compara.
 GO:0042176; P:regulation of protein catabolic process; IEA:Compara.
 GO:0010469; P:regulation of receptor activity; IEA:Compara. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.