CPLM-009396

Genbank Nucleotide ID

AP-1 complex subunit sigma-1A

Protein Synonyms/Alias

Adapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Clathrin assembly protein complex 1 sigma-1A small chain; Clathrin coat assembly protein AP19; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; HA1 19 kDa subunit; Sigma 1a subunit of AP-1 clathrin; Sigma-adaptin 1A; Sigma1A-adaptin

Homo sapiens (Human)

Position	Peptide	Type	References
18	QGKLRLQKWYLATSD	ubiquitination	[1]
26	WYLATSDKERKKMVR	ubiquitination	[1, 2]
56	FLEWRDLKVVYKRYA	ubiquitination	[1]
128	GDVQDTSKKSVLKAI	ubiquitination	[1]
133	TSKKSVLKAIEQADL	ubiquitination	[1, 3, 4, 5]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[3] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

MOD_RES 147 147 Phosphoserine.

Alternative splicing; Coated pit; Complete proteome; Cytoplasmic vesicle; Deafness; Endocytosis; Golgi apparatus; Ichthyosis; Membrane; Mental retardation; Neuropathy; Phosphoprotein; Protein transport; Reference proteome; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030121; C:AP-1 adaptor complex; TAS:UniProtKB.
GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005765; C:lysosomal membrane; TAS:Reactome.
GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
GO:0008565; F:protein transporter activity; IEA:InterPro.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
GO:0016044; P:cellular membrane organization; TAS:Reactome.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
GO:0006898; P:receptor-mediated endocytosis; TAS:UniProtKB.
GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
GO:0009615; P:response to virus; IEP:UniProtKB.
GO:0016032; P:viral reproduction; TAS:Reactome.

IPR016635; AP_complex_ssu.
IPR022775; AP_mu_sigma_su.
IPR000804; Clathrin_sm-chain_CS.
IPR011012; Longin-like_dom.

PF01217; Clat_adaptor_s

PS00989; CLAT_ADAPTOR_S