CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030802
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 19 
Protein Synonyms/Alias
 cDNA FLJ57049, highly similar to WD repeat protein 19 
Gene Name
 WDR19 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115IFQARNHKDNLTSIAubiquitination[1]
676RGVNQALKHPSRVLKubiquitination[1]
694GAILENMKQFSEAAQubiquitination[1, 2]
711EKGLYYDKAASVYIRubiquitination[1, 3]
780DHLNNPEKAVNIVREubiquitination[1]
795TQSLDGAKMVARFFLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1182 AA 
Protein Sequence
MITVSNQEGD TIRQTQVRSE PSNMQFFLMK MDDRTSAAES MISVVLGKKT LFFLNLNEPD 60
NPADLEFQQD FGNIVCYNWY GDGRIMIGFS CGHFVVISTH TGELGQEIFQ ARNHKDNLTS 120
IAVSQTLNKV ATCGDNCIKI QDLVDLKDMY VILNLDEENK GLGTLSWTDD GQLLALSTQR 180
GSLHVFLTKL PILGDACSTR IAYLTSLLEV TVANPVEGEL PITVSVDVEP NFVAVGLYHL 240
AVGMNNRAWF YVLGENAVKK LKDMEYLGTV ASICLHSDYA AALFEGKVQL HLIESEILDA 300
QEERETRLFP AVDDKCRILC HALTSDFLIY GTDTGVVQYF YIEDWQFVND YRHPVSVKKI 360
FPDPNGTRLV FIDEKSDGFV YCPVNDATYE IPDFSPTIKG VLWENWPMDK GVFIAYDDDK 420
VYTYVFHKDT IQGAKVILAG STKVPFAHKP LLLYNGELTC QTQSGKVNNI YLSTHGFLSN 480
LKDTGPDELR PMLAQNLMLK RFSDAWEMCR ILNDEAAWNE LARACLHHME VEFAIRVYRR 540
IGNVGIVMSL EQIKGIEDYN LLAGHLAMFT NDYNLAQDLY LASSCPIAAL EMRRDLQHWD 600
SALQLAKHLA PDQIPFISKE YAIQLEFAGD YVNALAHYEK GITGDNKEHD EACLAGVAQM 660
SIRMGDIRRG VNQALKHPSR VLKRDCGAIL ENMKQFSEAA QLYEKGLYYD KAASVYIRSK 720
NWAKVGDLLP HVSSPKIHLQ YAKAKEADGR YKEAVVAYEN AKQWQSVIRI YLDHLNNPEK 780
AVNIVRETQS LDGAKMVARF FLQLGDYGSA IQFLVMSKCN NEAFTLAQQH NKMEIYADII 840
GSEDTTNEDY QSIALYFEGE KRYLQAGKFF LLCGQYSRAL KHFLKCPSSE DNVAIEMAIE 900
TVGQAKDELL TNQLIDHLLG ENDGMPKDAK YLFRLYMALK QYREAAQTAI IIAREEQSAG 960
NYRNAHDVLF SMYAELKSQK IKIPSEMATN LMILHSYILV KIHVKNGDHM KGARMLIRVA 1020
NNISKFPSHI VPILTSTVIE CHRAGLKNSA FSFAAMLMRP EYRSKIDAKY KKKIEGMVRR 1080
PDISEIEEAT TPCPFCKFLL PECELLCPGC KNSIPYCIAT GRHMLKDDWT VCPHCDFPAL 1140
YSELKIMLNT ESTCPMCSER LNAAQLKKIS DCTQYLRTEE EL 1182 
Gene Ontology
 GO:0031514; C:motile cilium; IEA:Compara.
 GO:0032391; C:photoreceptor connecting cilium; IEA:Compara.
 GO:0060830; P:ciliary receptor clustering involved in smoothened signaling pathway; IEA:Compara.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0055123; P:digestive system development; IEA:Compara.
 GO:0042471; P:ear morphogenesis; IEA:Compara.
 GO:0031076; P:embryonic camera-type eye development; IEA:Compara.
 GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Compara.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0061055; P:myotome development; IEA:Compara.
 GO:0050877; P:neurological system process; IEA:Compara.
 GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Compara. 
Interpro
 IPR011990; TPR-like_helical.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
  
SMART
 SM00320; WD40 
PROSITE
  
PRINTS