CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033395
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA polymerase delta subunit 2 
Protein Synonyms/Alias
  
Gene Name
 POLD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88GSVRDDGKFLVEDYCubiquitination[1]
103FADLAPQKPAPPLDTubiquitination[1]
185KAKYLTKKTQAASVEubiquitination[2, 3, 4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 257 AA 
Protein Sequence
MFSEQAAQRA HTLLSPPSAN NATFARVPVA TYTNSSQPFR LGERSFSRQY AHIYATRLIQ 60
MRPFLENRAQ QHWGTVLAVF GSVRDDGKFL VEDYCFADLA PQKPAPPLDT DRFVLLVSGL 120
GLGGGGGESL LGTQLLVDVV TGQLGDEGEQ CSAAHVSRVI LAGNLLSHST QSRDSINKAK 180
YLTKKTQAAS VEAVKMLDEI LLQLSASVPV DVMPGEFDPT NYTLPQQPLH PCMFPLATAY 240
STLQLVTNPY QATIDGV 257 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:InterPro. 
Interpro
 IPR007185; DNA_pol_alpha/epsilon_bsu.
 IPR024826; DNA_pol_delta/II_ssu. 
Pfam
 PF04042; DNA_pol_E_B 
SMART
  
PROSITE
  
PRINTS