UniProt Accession

 YMDB_ECOLI; P0A8D6; P75918 

Genbank Protein ID

 U00096; AP009048 

Genbank Nucleotide ID

 AAC74129.1; BAA35835.1 

Protein Name

 O-acetyl-ADP-ribose deacetylase 

Protein Synonyms/Alias

 Regulator of RNase III activity 

Gene Name

 ymdB 

Gene Synonyms/Alias

 b1045; JW1032 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
52	ALLDACLKVRQQQGD	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation. 

Sequence Annotation

 DOMAIN 1 175 Macro.
 REGION 121 127 Substrate binding (Probable).
 ACT_SITE 35 35 Proton acceptor (Potential).  

Keyword

 3D-structure; Complete proteome; Hydrolase; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0061463; F:O-acetyl-ADP-ribose deacetylase activity; IDA:EcoCyc.
 GO:0001883; F:purine nucleoside binding; IEA:HAMAP.
 GO:0008428; F:ribonuclease inhibitor activity; IDA:EcoCyc.
 GO:0032074; P:negative regulation of nuclease activity; IDA:EcoCyc.
 GO:0060701; P:negative regulation of ribonuclease activity; IEA:HAMAP.
 GO:0042278; P:purine nucleoside metabolic process; IEA:HAMAP.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR002589; A1pp.
 IPR024900; O-Ac-ADP-ribose_deAcase. 

Pfam

 PF01661; Macro 

SMART

 SM00506; A1pp 

PROSITE

 PS51154; MACRO 

PRINTS