UniProt Accession

 PDLI7_MOUSE; Q3TJD7; Q80ZY6; Q810S3; Q8C1S4; Q9CRA1 

Genbank Protein ID

 AK003338; AK010141; AK003019; AK167476; BC045528; BC049565 

Genbank Nucleotide ID

 BAB22725.1; BAB26726.1; BAC25017.1; BAE39558.1; AAH45528.1; AAH49565.1 

Protein Name

 PDZ and LIM domain protein 7 

Protein Synonyms/Alias

 LIM mineralization protein; LMP; Protein enigma 

Gene Name

 Pdlim7 

Gene Synonyms/Alias

 Enigma 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	GFRLQGGKDFNVPLS	ubiquitination	[1]
238	AERYAPDKTSTVLTR	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). 

Sequence Annotation

 DOMAIN 1 85 PDZ.
 DOMAIN 280 338 LIM zinc-binding 1.
 DOMAIN 339 398 LIM zinc-binding 2.
 DOMAIN 399 457 LIM zinc-binding 3.
 MOD_RES 247 247 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; LIM domain; Metal-binding; Osteogenesis; Phosphoprotein; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 457 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0001726; C:ruffle; IDA:MGI.
 GO:0001725; C:stress fiber; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IPI:MGI.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0001503; P:ossification; IEA:UniProtKB-KW.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara. 

Interpro

 IPR001478; PDZ.
 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM
 PF00595; PDZ 

SMART

 SM00132; LIM
 SM00228; PDZ 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS50106; PDZ 

PRINTS