CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001729
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 1A1 
Protein Synonyms/Alias
 CYPIA1; Cytochrome P450-P1 
Gene Name
 Cyp1a1 
Gene Synonyms/Alias
 Cyp1a-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
97LSGLNTIKQALVRQGubiquitination[1]
108VRQGDDFKGRPDLYSubiquitination[1]
123FTLITNGKSMTFNPDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. 
Sequence Annotation
 METAL 461 461 Iron (heme axial ligand) (By similarity).
 BINDING 228 228 Substrate (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 524 AA 
Protein Sequence
MPSMYGLPAF VSATELLLAV TVFCLGFWVV RATRTWVPKG LKTPPGPWGL PFIGHMLTVG 60
KNPHLSLTRL SQQYGDVLQI RIGSTPVVVL SGLNTIKQAL VRQGDDFKGR PDLYSFTLIT 120
NGKSMTFNPD SGPVWAARRR LAQNALKSFS IASDPTSASS CYLEEHVSKE ANYLVSKLQK 180
VMAEVGHFDP YKYLVVSVAN VICAICFGQR YDHDDQELLS IVNLSNEFGE VTGSGYPADF 240
IPVLRYLPNS SLDAFKDLND KFYSFMKKLI KEHYRTFEKG HIRDITDSLI EHCQDRKLDE 300
NANVQLSDDK VITIVLDLFG AGFDTVTTAI SWSLMYLVTN PRVQRKIQEE LDTVIGRDRQ 360
PRLSDRPQLP YLEAFILETF RHSSFVPFTI PHSTTRDTSL NGFYIPKGCC VFVNQWQVNH 420
DRELWGDPNE FRPERFLTPS GTLDKRLSEK VTLFGLGKRK CIGETIGRSE VFLFLAILLQ 480
QIEFKVSPGE KVDMTPTYGL TLKHARCEHF QVQMRSSGPQ HLQA 524 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0032451; F:demethylase activity; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0016711; F:flavonoid 3'-monooxygenase activity; IEA:Compara.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016679; F:oxidoreductase activity, acting on diphenols and related substances as donors; IEA:Compara.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IDA:MGI.
 GO:0008395; F:steroid hydroxylase activity; IEA:Compara.
 GO:0070576; F:vitamin D 24-hydroxylase activity; IEA:Compara.
 GO:0042904; P:9-cis-retinoic acid biosynthetic process; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0009308; P:amine metabolic process; IMP:MGI.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0008283; P:cell proliferation; IEA:Compara.
 GO:0009804; P:coumarin metabolic process; IEA:Compara.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0017144; P:drug metabolic process; IEA:Compara.
 GO:0009792; P:embryo development ending in birth or egg hatching; IEA:Compara.
 GO:0009812; P:flavonoid metabolic process; IEA:Compara.
 GO:0070365; P:hepatocyte differentiation; IEA:Compara.
 GO:0046483; P:heterocycle metabolic process; IMP:MGI.
 GO:0050665; P:hydrogen peroxide biosynthetic process; IMP:MGI.
 GO:0017143; P:insecticide metabolic process; IEA:Compara.
 GO:0060137; P:maternal process involved in parturition; IEA:Compara.
 GO:0006778; P:porphyrin-containing compound metabolic process; IEA:Compara.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0046685; P:response to arsenic-containing substance; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032094; P:response to food; IEA:Compara.
 GO:0009635; P:response to herbicide; IEA:Compara.
 GO:0055093; P:response to hyperoxia; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0010041; P:response to iron(III) ion; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0009624; P:response to nematode; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0009636; P:response to toxic substance; IMP:MGI.
 GO:0009615; P:response to virus; IEA:Compara.
 GO:0033189; P:response to vitamin A; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0009404; P:toxin metabolic process; IMP:MGI. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008066; Cyt_P450_E_grp-I_CYP1. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR01683; EP450ICYP1A.
 PR00385; P450.