CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002437
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histidine transport ATP-binding protein HisP 
Protein Synonyms/Alias
  
Gene Name
 hisP 
Gene Synonyms/Alias
 b2306; JW2303 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
13LNVIDLHKRYGEHEVacetylation[1]
22YGEHEVLKGVSLQANacetylation[1]
56RCINFLEKPSEGSIVacetylation[1]
80RDKDGQLKVADKNQLacetylation[1]
84GQLKVADKNQLRLLRacetylation[1]
138RAVKYLAKVGIDERAacetylation[1]
148IDERAQGKYPVHLSGacetylation[1]
203QQLAEEGKTMVVVTHacetylation[1]
229VIFLHQGKIEEEGAPacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system. 
Sequence Annotation
 DOMAIN 6 252 ABC transporter.
 NP_BIND 38 45 ATP (By similarity).  
Keyword
 Amino-acid transport; ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Nucleotide-binding; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 257 AA 
Protein Sequence
MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC INFLEKPSEG 60
SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH FNLWSHMTVL ENVMEAPIQV 120
LGLSKQEARE RAVKYLAKVG IDERAQGKYP VHLSGGQQQR VSIARALAME PEVLLFDEPT 180
SALDPELVGE VLRIMQQLAE EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF 240
GNPQSPRLQR FLKGSLK 257 
Gene Ontology
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0000105; P:histidine biosynthetic process; IMP:EcoliWiki.
 GO:0015817; P:histidine transport; IMP:EcoliWiki. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS