CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035041
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp8 
Gene Synonyms/Alias
 Usp8_predicted; rCG_27002 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
125VRKQLEEKDRREEEQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1081 AA 
Protein Sequence
MPAVASVPKE LYLSSSLKDL NKKTEVKPEK TSTKNYIHSA QKIFKAAEEC RLDRDEERAY 60
VLYMKYVAVY NLIKKRPDFK QQQDYYLSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK 120
QLEEKDRREE EQLQQQKRQE MGREDSGAAA KRSVENLLDS KTKIQRVNGE KSEGGAAAER 180
GAVTAKELYT MMMDKNTSLI IMDARKIQDY QHSCILGSLS VPEEAISPGV TANWIEAKLS 240
DDSKDTWKKR GSVDYVVLLD WFSSAKDLLL GTTLRSLKDA LFKWESKAVL HHEPLVLEGG 300
YENWLLCYPQ FTTNAKVTPP PRSRPEEVSV SLDFTYPSLE EPVPSKLPAQ MPPPPLEANE 360
KAQLVTDQDG KPRPLVQSAL AGPSVAPKAE ASPIIQPVPA TKNVPQVDRT KKPAVKLPED 420
HRMKSESTDQ SGRVLSDRST KPVFTSPATM LTDEEKARIH EETALLMEKN RQEKELWERQ 480
QKEQKEKLRR EEQERKAGKT QDAEERDFTE NQHKAKDGQE KRDSKQTKAE DREPPADGAQ 540
DATGTQRQSK SEHDASDAKV SVEGKRCPMS EVQKRPADVS SASSMSGELS AGKAQREPLT 600
RARSEEMGRI VPGLPLGWAK FLDPITGTFR YYHSPTNTVH MYPPEMAPSS VPPSTPPTHK 660
VKPQIPAERD REPSKLKRSY SSPDITQALQ EEEKRRPAVT PTVNRENKPP CYPKAEISRL 720
SASQIRNLNP VFGGSGPALT GLRNLGNTCY MNSILQCLCN APHLADYFNR NCYQDDINRS 780
NLLGHKGEVA EEFGIIMKAL WTGQYRYISP KDFKVTIGKI NDQFAGSSQQ DSQELLLFLM 840
DGLHEDLNKA DNRKRHKEEN NDHLDDFKAA EHAWQKHKQL NESIIVALFQ GQFKSTVQCL 900
TCHKKSRTFE AFMYLSLPLA STSKCTLQDC LRLFSKEEKL TDNNRFYCSH CRARRDSLKK 960
IEIWKLPPVL LVHLKRFSYD GRWKQKLQTS VDFPLENLDL SQYVIGPKSS LKKYNLFSVS 1020
NHYGGLDGGH YTAYCKNAAR QRWFKFDDHE VSDISVSSVR SSAAYILFYT SLGPRVTEAA 1080
T 1081 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005769; C:early endosome; IEA:Compara.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0004843; F:ubiquitin-specific protease activity; IEA:Compara.
 GO:0007032; P:endosome organization; IEA:Compara.
 GO:0000281; P:mitotic cytokinesis; IEA:Compara.
 GO:0071108; P:protein K48-linked deubiquitination; IEA:Compara.
 GO:0070536; P:protein K63-linked deubiquitination; IEA:Compara.
 GO:0007265; P:Ras protein signal transduction; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR015063; DUF1873.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR001763; Rhodanese-like_dom. 
Pfam
 PF08969; DUF1873
 PF00581; Rhodanese
 PF00443; UCH 
SMART
 SM00450; RHOD 
PROSITE
 PS50206; RHODANESE_3
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS