CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003894
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetylcholine receptor subunit beta 
Protein Synonyms/Alias
  
Gene Name
 CHRNB1 
Gene Synonyms/Alias
 ACHRB; CHRNB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
353VRQIFIHKLPLYLRLubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
Sequence Annotation
 MOD_RES 390 390 Phosphotyrosine; by Tyr-kinases (By
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 DISULFID 151 165 By similarity.  
Keyword
 Cell junction; Cell membrane; Complete proteome; Congenital myasthenic syndrome; Disease mutation; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 501 AA 
Protein Sequence
MTPGALLMLL GALGAPLAPG VRGSEAEGRL REKLFSGYDS SVRPAREVGD RVRVSVGLIL 60
AQLISLNEKD EEMSTKVYLD LEWTDYRLSW DPAEHDGIDS LRITAESVWL PDVVLLNNND 120
GNFDVALDIS VVVSSDGSVR WQPPGIYRSS CSIQVTYFPF DWQNCTMVFS SYSYDSSEVS 180
LQTGLGPDGQ GHQEIHIHEG TFIENGQWEI IHKPSRLIQP PGDPRGGREG QRQEVIFYLI 240
IRRKPLFYLV NVIAPCILIT LLAIFVFYLP PDAGEKMGLS IFALLTLTVF LLLLADKVPE 300
TSLSVPIIIK YLMFTMVLVT FSVILSVVVL NLHHRSPHTH QMPLWVRQIF IHKLPLYLRL 360
KRPKPERDLM PEPPHCSSPG SGWGRGTDEY FIRKPPSDFL FPKPNRFQPE LSAPDLRRFI 420
DGPNRAVALL PELREVVSSI SYIARQLQEQ EDHDALKEDW QFVAMVVDRL FLWTFIIFTS 480
VGTLVIFLDA TYHLPPPDPF P 501 
Gene Ontology
 GO:0005892; C:acetylcholine-gated channel complex; IMP:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IMP:UniProtKB.
 GO:0042166; F:acetylcholine binding; ISS:UniProtKB.
 GO:0004889; F:acetylcholine-activated cation-selective channel activity; IEA:Compara.
 GO:0015276; F:ligand-gated ion channel activity; ISS:UniProtKB.
 GO:0035095; P:behavioral response to nicotine; IMP:UniProtKB.
 GO:0006812; P:cation transport; IMP:UniProtKB.
 GO:0006936; P:muscle contraction; IMP:UniProtKB.
 GO:0048747; P:muscle fiber development; IMP:UniProtKB.
 GO:0007274; P:neuromuscular synaptic transmission; IMP:UniProtKB.
 GO:0001941; P:postsynaptic membrane organization; IMP:UniProtKB.
 GO:0042391; P:regulation of membrane potential; ISS:UniProtKB.
 GO:0007165; P:signal transduction; IMP:UniProtKB.
 GO:0007271; P:synaptic transmission, cholinergic; IMP:UniProtKB. 
Interpro
 IPR027361; Acetylcholine_rcpt_TM.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS.
 IPR002394; Nicotinic_acetylcholine_rcpt. 
Pfam
 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 
SMART
  
PROSITE
 PS00236; NEUROTR_ION_CHANNEL 
PRINTS
 PR00254; NICOTINICR.
 PR00252; NRIONCHANNEL.