CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008468
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lysine decarboxylase, constitutive 
Protein Synonyms/Alias
 LDC 
Gene Name
 ldcC 
Gene Synonyms/Alias
 ldc; ldcH; b0186; JW0181 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
595DLAQGIHKLIRKHDLacetylation[1]
667MPGEMLTKESRTVLDacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 LDC is constitutively but weakly expressed under various conditions. 
Sequence Annotation
 MOD_RES 367 367 N6-(pyridoxal phosphate)lysine.  
Keyword
 Complete proteome; Decarboxylase; Direct protein sequencing; Lyase; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 713 AA 
Protein Sequence
MNIIAIMGPH GVFYKDEPIK ELESALVAQG FQIIWPQNSV DLLKFIEHNP RICGVIFDWD 60
EYSLDLCSDI NQLNEYLPLY AFINTHSTMD VSVQDMRMAL WFFEYALGQA EDIAIRMRQY 120
TDEYLDNITP PFTKALFTYV KERKYTFCTP GHMGGTAYQK SPVGCLFYDF FGGNTLKADV 180
SISVTELGSL LDHTGPHLEA EEYIARTFGA EQSYIVTNGT STSNKIVGMY AAPSGSTLLI 240
DRNCHKSLAH LLMMNDVVPV WLKPTRNALG ILGGIPRREF TRDSIEEKVA ATTQAQWPVH 300
AVITNSTYDG LLYNTDWIKQ TLDVPSIHFD SAWVPYTHFH PIYQGKSGMS GERVAGKVIF 360
ETQSTHKMLA ALSQASLIHI KGEYDEEAFN EAFMMHTTTS PSYPIVASVE TAAAMLRGNP 420
GKRLINRSVE RALHFRKEVQ RLREESDGWF FDIWQPPQVD EAECWPVAPG EQWHGFNDAD 480
ADHMFLDPVK VTILTPGMDE QGNMSEEGIP AALVAKFLDE RGIVVEKTGP YNLLFLFSIG 540
IDKTKAMGLL RGLTEFKRSY DLNLRIKNML PDLYAEDPDF YRNMRIQDLA QGIHKLIRKH 600
DLPGLMLRAF DTLPEMIMTP HQAWQRQIKG EVETIALEQL VGRVSANMIL PYPPGVPLLM 660
PGEMLTKESR TVLDFLLMLC SVGQHYPGFE TDIHGAKQDE DGVYRVRVLK MAG 713 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0008923; F:lysine decarboxylase activity; IDA:EcoCyc.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006554; P:lysine catabolic process; IDA:EcoliWiki. 
Interpro
 IPR005308; OKR_de-COase_N.
 IPR011193; Orn/lys/arg_de-COase.
 IPR000310; Orn/Lys/Arg_deCO2ase_major_dom.
 IPR008286; Prn/Lys/Arg_de-COase_C.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF01276; OKR_DC_1
 PF03711; OKR_DC_1_C
 PF03709; OKR_DC_1_N 
SMART
  
PROSITE
 PS00703; OKR_DC_1 
PRINTS