UniProt Accession

 PSA2_RAT; P17220 

Genbank Protein ID

 J02897 

Genbank Nucleotide ID

 AAA40838.1 

Protein Name

 Proteasome subunit alpha type-2 

Protein Synonyms/Alias

 Macropain subunit C3; Multicatalytic endopeptidase complex subunit C3; Proteasome component C3 

Gene Name

 Psma2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
51	VVLATEKKQKSILYD	acetylation	[1]
53	LATEKKQKSILYDER	acetylation	[1]
64	YDERSVHKVEPITKH	acetylation	[1]
70	HKVEPITKHIGLVYS	ubiquitination	[2]
92	VLVHRARKLAQQYYL	acetylation	[1]
171	GKNYVNGKTFLEKRY	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 70 70 N6-acetyllysine (By similarity).
 MOD_RES 76 76 Phosphotyrosine (By similarity).
 MOD_RES 121 121 Phosphotyrosine (Probable).
 MOD_RES 171 171 N6-acetyllysine (By similarity).
 MOD_RES 229 229 Nitrated tyrosine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nitration; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 234 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005839; C:proteasome core complex; ISS:UniProtKB.
 GO:0019773; C:proteasome core complex, alpha-subunit complex; IEA:InterPro.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 

Interpro

 IPR000426; Proteasome_asu_N.
 IPR023332; Proteasome_suA-type.
 IPR001353; Proteasome_sua/b. 

Pfam

 PF00227; Proteasome
 PF10584; Proteasome_A_N 

SMART

 SM00948; Proteasome_A_N 

PROSITE

 PS00388; PROTEASOME_A_1
 PS51475; PROTEASOME_A_2 

PRINTS