CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015723
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transitional endoplasmic reticulum ATPase TER94 
Protein Synonyms/Alias
 Valosin-containing protein homolog 
Gene Name
 TER94 
Gene Synonyms/Alias
 VCP; CG2331 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
5***MADSKGEDLATAacetylation[1]
15DLATAILKRKDRPNRacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Involved in the ubiquitin-proteasome system. Important for oskar mRNA localization and/or anchoring during oogenesis. Involved in germ cell formation. 
Sequence Annotation
 NP_BIND 244 250 ATP (By similarity).
 BINDING 345 345 ATP (By similarity).
 BINDING 381 381 ATP (By similarity).
 MOD_RES 716 716 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Hydrolase; Nucleotide-binding; Nucleus; Oogenesis; Phosphoprotein; Reference proteome; Transport; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 801 AA 
Protein Sequence
MADSKGEDLA TAILKRKDRP NRLIVEEAQN DDNSVVSLSQ AKMDELQLFR GDTVILKGKR 60
RKETVCIVLS DDTCPDEKIR MNRVVRNNLC VHLSDVVSVQ SCPDVKYGKR VRILPIDEST 120
EGVTGNLFEI YLKPYFLEAY RPIHMGDNFI VRAAMRPIEF KVVLTDPEPY CIVAPETVIF 180
CDGDPIKREE EEESLNAVGY DDIGGCRKQL AQIKEMVELP LRHPSLFKAI GVKPPRGILM 240
YGPPGTGKTL IARAVANETG AFFFLINGPE IMSKLAGESE SNLRKAFEEA EKNSPAIIFI 300
DEIDAIAPKR DKTHGEVERR IVSQLLTLMD GMKKSSHLIV MAATNRPNSI DPALRRFGRF 360
DREIDIGIPD ATGRLEVLRI HTKNMKLHDD VDLEQIAAES HGHVGADLAS LCSEAALQQI 420
REKMDLIDLE DDKIDAEVLA SLAVTMENFR YAMTKSSPSA LRETVVEVPN TTWTDIGGLE 480
SVKKELQELV QYPVEHPDKF LKFGMQPSRG VLFYGPPGCG KTLLAKAIAN ECQANFISVK 540
GPELLTMWFG ESEANVRDIF DKARSAAPCV LFFDELDSIA KARGGNVGDA GGAADRVINQ 600
ILTEMDGMGA KKNVFIIGAT NRPDIIDPAI LRPGRLDQLI YIPLPDDKSR EAILKANLRK 660
SPLAKEVDLT YIAKVTQGFS GADLTEICQR ACKLAIRQAI EAEIRREKER AENQNSAMDM 720
DEDDPVPEIT SAHFEEAMKF ARRSVSDNDI RKYEMFAQTL QQSRGFGQNF RFPGQTGNTS 780
GSGNNLPVNS PGDNGDDDLY S 801 
Gene Ontology
 GO:0045169; C:fusome; IDA:FlyBase.
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000502; C:proteasome complex; NAS:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IGI:FlyBase.
 GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
 GO:0016320; P:endoplasmic reticulum membrane fusion; ISS:FlyBase.
 GO:0007029; P:endoplasmic reticulum organization; IMP:FlyBase.
 GO:0030433; P:ER-associated protein catabolic process; IMP:FlyBase.
 GO:0007030; P:Golgi organization; IMP:FlyBase.
 GO:0000226; P:microtubule cytoskeleton organization; IMP:FlyBase.
 GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:FlyBase.
 GO:0043523; P:regulation of neuron apoptotic process; IMP:FlyBase.
 GO:0007317; P:regulation of pole plasm oskar mRNA localization; IMP:FlyBase.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR009010; Asp_de-COase-like_dom.
 IPR005938; ATPase_AAA_CDC48.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR004201; Cdc48_dom2.
 IPR003338; CDC4_N-term_subdom.
 IPR027417; P-loop_NTPase.
 IPR015415; Vps4_C. 
Pfam
 PF00004; AAA
 PF02933; CDC48_2
 PF02359; CDC48_N
 PF09336; Vps4_C 
SMART
 SM00382; AAA
 SM01072; CDC48_2
 SM01073; CDC48_N 
PROSITE
 PS00674; AAA 
PRINTS