UniProt Accession

 H4_SEPOF; Q7M3Z5 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Sepia officinalis (Common cuttlefish) 

NCBI Taxa ID

 6610 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKGGKGLGK	acetylation	[1]
13	KGGKGLGKGGAKR**	acetylation	[1]
17	GLGKGGAKR******	acetylation	[1]

Reference

 [1] Histone H4 from cuttlefish testis is sequentially acetylated. Comparison with acetylation of calf thymus histone H4.
 Couppez M, Martin-Ponthieu A, Sautière P.
 J Biol Chem. 1987 Feb 25;262(6):2854-60. [PMID: 3818624] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 6 6 N6-acetyllysine; partial.
 MOD_RES 13 13 N6-acetyllysine; partial.
 MOD_RES 17 17 N6-acetyllysine; partial.  

Keyword

 Acetylation; Chromosome; Direct protein sequencing; DNA-binding; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 18 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

PROSITE

 PS00047; HISTONE_H4 

PRINTS