CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000447
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Baculoviral IAP repeat-containing protein 5 
Protein Synonyms/Alias
 Apoptosis inhibitor 4; Apoptosis inhibitor survivin 
Gene Name
 BIRC5 
Gene Synonyms/Alias
 API4; IAP4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23DHRISTFKNWPFLEGacetylation[1]
78DDPIEEHKKHSSGCAubiquitination[2]
90GCAFLSVKKQFEELTacetylation[1]
103LTLGEFLKLDRERAKubiquitination[2]
110KLDRERAKNKIAKETacetylation[1]
112DRERAKNKIAKETNNacetylation[1]
115RAKNKIAKETNNKKKacetylation[1]
120IAKETNNKKKEFEETacetylation[1]
121AKETNNKKKEFEETAacetylation[1]
122KETNNKKKEFEETAKacetylation[1]
129KEFEETAKKVRRAIEacetylation[1]
130EFEETAKKVRRAIEQacetylation[1]
Reference
 [1] Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.
 Wang H, Holloway MP, Ma L, Cooper ZA, Riolo M, Samkari A, Elenitoba-Johnson KS, Chin YE, Altura RA.
 J Biol Chem. 2010 Nov 12;285(46):36129-37. [PMID: 20826784]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. 
Sequence Annotation
 REPEAT 18 88 BIR.
 METAL 57 57 Zinc.
 METAL 60 60 Zinc.
 METAL 77 77 Zinc.
 METAL 84 84 Zinc.
 MOD_RES 23 23 N6-acetyllysine.
 MOD_RES 34 34 Phosphothreonine; by CDK1.
 MOD_RES 48 48 Phosphothreonine; by CK2; in vitro.
 MOD_RES 90 90 N6-acetyllysine.
 MOD_RES 110 110 N6-acetyllysine.
 MOD_RES 112 112 N6-acetyllysine.
 MOD_RES 115 115 N6-acetyllysine.
 MOD_RES 117 117 Phosphothreonine; by AURKB.
 MOD_RES 121 121 N6-acetyllysine.
 MOD_RES 129 129 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Apoptosis; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Cytoplasm; Cytoskeleton; Kinetochore; Metal-binding; Microtubule; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Protease inhibitor; Reference proteome; Repressor; Thiol protease inhibitor; Transcription; Transcription regulation; Ubl conjugation; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 142 AA 
Protein Sequence
MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC 60
FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK 120
KKEFEETAKK VRRAIEQLAA MD 142 
Gene Ontology
 GO:0005814; C:centriole; IDA:UniProtKB.
 GO:0032133; C:chromosome passenger complex; IPI:UniProtKB.
 GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.
 GO:0000777; C:condensed chromosome kinetochore; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0031021; C:interphase microtubule organizing center; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0000228; C:nuclear chromosome; IDA:UniProtKB.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0005876; C:spindle microtubule; IDA:UniProtKB.
 GO:0050897; F:cobalt ion binding; NAS:UniProtKB.
 GO:0048037; F:cofactor binding; IDA:UniProtKB.
 GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IMP:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008017; F:microtubule binding; IDA:UniProtKB.
 GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
 GO:0000910; P:cytokinesis; IMP:UniProtKB.
 GO:0051303; P:establishment of chromosome localization; IMP:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; TAS:UniProtKB.
 GO:0031536; P:positive regulation of exit from mitosis; IMP:UniProtKB.
 GO:0045931; P:positive regulation of mitotic cell cycle; IMP:UniProtKB.
 GO:0031503; P:protein complex localization; IMP:UniProtKB.
 GO:0006468; P:protein phosphorylation; IDA:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
 GO:0031577; P:spindle checkpoint; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001370; BIR. 
Pfam
 PF00653; BIR 
SMART
 SM00238; BIR 
PROSITE
 PS01282; BIR_REPEAT_1
 PS50143; BIR_REPEAT_2 
PRINTS