CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037055
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 NDUFA10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
48WHFLLGDKASKRLTEubiquitination[1]
102DSTTGDGKPLATDYNubiquitination[1]
181YNQGFIRKQCVDHYNubiquitination[2]
242QDIENAYKKTFLPEMubiquitination[3]
243DIENAYKKTFLPEMSubiquitination[1, 4]
277VEDIEYLKFDKGPWLubiquitination[1, 3, 4, 5]
280IEYLKFDKGPWLKQDubiquitination[1, 4]
285FDKGPWLKQDNRTLYubiquitination[1, 3, 4, 5]
373GLQLPGRKYSPGYNTubiquitination[1, 4, 5]
385YNTEVGDKWIWLK**ubiquitination[1, 4]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MALRLLKLAA TSASARVVAA GAQRVRGIHS SVQCKLRYGM WHFLLGDKAS KRLTERSRVI 60
TVDGNICTGK GKLAKEIAEK LGFKHFPEAG IHYPDSTTGD GKPLATDYNG NCSLEKFYDD 120
PRSNDGNSYR LQSWLYSSRL LQYSDALEHL LTTGQGVVLE RSIFSDFVFL EAMYNQGFIR 180
KQCVDHYNEV KSVTICDYLP PHLVIYIDVP VPEVQRRIQK KGDPHEMKIT SAYLQDIENA 240
YKKTFLPEMS EKCEVLQYSA REAQDSKKVV EDIEYLKFDK GPWLKQDNRT LYHLRLLVQD 300
KFEVLNYTSI PIFLPEVTIG AHQTDRVLHQ FRELGIPYPQ RAVQSTREGP EVLLTGLWRW 360
EDLLIGLQLP GRKYSPGYNT EVGDKWIWLK 390 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro. 
Interpro
 IPR002624; Deoxynucleoside_kinase.
 IPR015828; NADH_UbQ_OxRdtase_42KD_su.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01712; dNK 
SMART
  
PROSITE
  
PRINTS