UniProt Accession

 IL2RG_HUMAN; P31785; Q5FC12 

Genbank Protein ID

 D11086; L12183; L12178; L12176; L12177; L12179; L12180; L12181; L12182; L19546; AB102794; AY692262; AL590764; BC014972 

Genbank Nucleotide ID

 BAA01857.1; AAA59145.1; AAA59145.1; AAA59145.1; AAA59145.1; AAA59145.1; AAA59145.1; AAA59145.1; AAA59145.1; AAC37524.1; BAD89385.1; AAT85803.1; AAH14972.1 

Protein Name

 Cytokine receptor common subunit gamma 

Protein Synonyms/Alias

 Interleukin-2 receptor subunit gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; gammaC; p64; CD132 

Gene Name

 IL2RG 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
98	YKNSDNDKVQKCSHY	ubiquitination	[1]
101	SDNDKVQKCSHYLFS	ubiquitination	[1]
119	TSGCQLQKKEIHLYQ	ubiquitination	[1]
120	SGCQLQKKEIHLYQT	ubiquitination	[1]
147	RQATQMLKLQNLVIP	ubiquitination	[1]
207	QSVDYRHKFSLPSVD	ubiquitination	[1, 2]
217	LPSVDGQKRYTFRVR	ubiquitination	[1]
294	MPRIPTLKNLEDLVT	ubiquitination	[3, 4]
315	SAWSGVSKGLAESLQ	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Common subunit for the receptors for a variety of interleukins. 

Sequence Annotation

 DOMAIN 154 241 Fibronectin type-III.
 MOTIF 237 241 WSXWS motif.
 MOTIF 286 294 Box 1 motif.
 MOD_RES 161 161 Phosphothreonine (By similarity).
 MOD_RES 292 292 Phosphothreonine.
 MOD_RES 325 325 Phosphotyrosine (By similarity).
 CARBOHYD 24 24 N-linked (GlcNAc...) (Potential).
 CARBOHYD 71 71 N-linked (GlcNAc...).
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 84 84 N-linked (GlcNAc...).
 CARBOHYD 159 159 N-linked (GlcNAc...).
 CARBOHYD 249 249 N-linked (GlcNAc...) (Potential).
 DISULFID 62 72
 DISULFID 102 115
 DISULFID 182 231  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Host-virus interaction; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; SCID; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004896; F:cytokine receptor activity; IEA:InterPro.
 GO:0019976; F:interleukin-2 binding; ISS:UniProtKB.
 GO:0006955; P:immune response; TAS:ProtInc.
 GO:0038110; P:interleukin-2-mediated signaling pathway; TAS:GOC.
 GO:0035771; P:interleukin-4-mediated signaling pathway; TAS:GOC.
 GO:0038111; P:interleukin-7-mediated signaling pathway; TAS:GOC.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR003531; Hempt_rcpt_S_F1_CS.
 IPR013783; Ig-like_fold.
 IPR015321; IL6_recept-bd. 

Pfam

 PF00041; fn3
 PF09240; IL6Ra-bind 

SMART

 SM00060; FN3 

PROSITE

 PS50853; FN3
 PS01355; HEMATOPO_REC_S_F1 

PRINTS