CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024579
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nucleoside diphosphate-linked moiety X motif 19, mitochondrial 
Protein Synonyms/Alias
 Nudix motif 19 
Gene Name
 NUDT19 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
111LPDTDDHKTDNTGTLubiquitination[1, 2]
278ASLSDLHKFCLGRALubiquitination[2]
328NLMSTEKKTEEIMKEubiquitination[1]
334KKTEEIMKEGKQFHRubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched- chain fatty-acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (By similarity). 
Sequence Annotation
 DOMAIN 15 263 Nudix hydrolase.
 MOTIF 116 137 Nudix box.
 MOTIF 373 375 Microbody targeting signal (Potential).
 METAL 131 131 Magnesium or manganese (By similarity).
 METAL 135 135 Magnesium or manganese (By similarity).  
Keyword
 Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Mitochondrion; Peroxisome; Polymorphism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 375 AA 
Protein Sequence
MSSSLRPGPS RWRRAASIVL AAGWSRPETA TPPSRPPPAE GFRLLLLQRS PHQGFMPGAH 60
VFSGGVLDAA DRSADWLGLF APHHGPPRFG LGPAPFSRTA FPSLPDTDDH KTDNTGTLPE 120
DVAFRICAVR EAFEEAGVLL LRPRTSPPGP APGPGLALEP PPGLASWRDR VRQDPRHFLR 180
LCAHLDCTPD IWALHNWSAW LTPFLRGTTR RFDTAFFLCC LREPPPVYPD LAEVVGYQWS 240
SPSEATESFL SKEIWLPPPQ FYEVRRLANF ASLSDLHKFC LGRALEGLER WLPIILLTAD 300
GMVHLLPGDE LYLEDSDFLE NLMSTEKKTE EIMKEGKQFH RIVTYHRHLY DIHVTVQPKY 360
KHVYPKNSVV RKSHL 375 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 
Pfam
 PF00293; NUDIX 
SMART
  
PROSITE
 PS51462; NUDIX
 PS00893; NUDIX_BOX 
PRINTS