UniProt Accession

 VATE1_HUMAN; P36543; A8MUE4; A8MUN4 

Genbank Protein ID

 X76228; X71491; CR456385; AK294623; AK315941; AC004019; AC006285; AC007666; BC004443 

Genbank Nucleotide ID

 CAA53814.1; CAA50592.1; CAG30271.1; BAG57804.1; BAH14312.1; AAH04443.1 

Protein Name

 V-type proton ATPase subunit E 1 

Protein Synonyms/Alias

 V-ATPase subunit E 1; V-ATPase 31 kDa subunit; p31; Vacuolar proton pump subunit E 1 

Gene Name

 ATP6V1E1 

Gene Synonyms/Alias

 ATP6E; ATP6E2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
10	LSDADVQKQIKHMMA	ubiquitination	[1, 2]
42	EEEFNIEKGRLVQTQ	ubiquitination	[1, 3]
99	TDLLNEAKQRLSKVV	ubiquitination	[1]
138	RMIVRCRKQDFPLVK	ubiquitination	[3]
145	KQDFPLVKAAVQKAI	ubiquitination	[1]
156	QKAIPMYKIATKNDV	ubiquitination	[4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 56 56 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Hydrolase; Ion transport; Phosphoprotein; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016469; C:proton-transporting two-sector ATPase complex; TAS:ProtInc.
 GO:0033178; C:proton-transporting two-sector ATPase complex, catalytic domain; IEA:InterPro.
 GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; IEA:Compara.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:Compara.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0051701; P:interaction with host; TAS:Reactome.
 GO:0090382; P:phagosome maturation; TAS:Reactome.
 GO:0015992; P:proton transport; TAS:ProtInc.
 GO:0033572; P:transferrin transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR002842; ATPase_V1/A1-cplx_esu. 

Pfam

 PF01991; vATP-synt_E 

SMART

  

PROSITE

  

PRINTS