| Tag | Content |
|---|
| CPLM ID | CPLM-011254 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Macrophage-stimulating protein receptor |
Protein Synonyms/Alias | MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-Ron; CD136; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain |
Gene Name | MST1R |
Gene Synonyms/Alias | PTK8; RON |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 222 | SVSIRRLKADASGFA | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. |
Sequence Annotation | DOMAIN 31 522 Sema.
DOMAIN 569 671 IPT/TIG 1.
DOMAIN 684 767 IPT/TIG 2.
DOMAIN 770 860 IPT/TIG 3.
DOMAIN 1082 1345 Protein kinase.
NP_BIND 1088 1096 ATP.
NP_BIND 1161 1164 ATP.
ACT_SITE 1208 1208 Proton acceptor (Probable).
BINDING 1114 1114 ATP.
BINDING 1212 1212 ATP.
MOD_RES 1238 1238 Phosphotyrosine; by autocatalysis
MOD_RES 1239 1239 Phosphotyrosine; by autocatalysis
MOD_RES 1353 1353 Phosphotyrosine; by autocatalysis.
MOD_RES 1360 1360 Phosphotyrosine; by autocatalysis.
CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
CARBOHYD 419 419 N-linked (GlcNAc...) (Potential).
CARBOHYD 458 458 N-linked (GlcNAc...) (Potential).
CARBOHYD 488 488 N-linked (GlcNAc...).
CARBOHYD 654 654 N-linked (GlcNAc...) (Potential).
CARBOHYD 720 720 N-linked (GlcNAc...) (Potential).
CARBOHYD 841 841 N-linked (GlcNAc...) (Potential).
CARBOHYD 897 897 N-linked (GlcNAc...) (Potential).
DISULFID 101 104
DISULFID 107 162
DISULFID 135 143
DISULFID 174 177
DISULFID 300 367
DISULFID 385 407
DISULFID 386 422
DISULFID 527 545
DISULFID 533 567
DISULFID 536 552
DISULFID 548 558 |
Keyword | 3D-structure; Alternative splicing; ATP-binding; Cleavage on pair of basic residues; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Innate immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1400 AA |
Protein Sequence | MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT 60
YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT 120
KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS 180
PLGTRVTVVE QGQASYFYVA SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPK 240
HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC 300
RFAPKRRRRG APEGGQPYPV LRVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV 360
GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP PGLEALSPNT 420
SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELVRSL 480
NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIQGPGCRHF LTCGRCLRAW 540
HFMGCGWCGN MCGQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG 600
LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT 660
NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN 720
GTECLLARVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFQYREDP VVLSISPNCG 780
YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG 840
NLSARGDGAA GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGINVTV 900
GGESCQHEFR GDMVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVRPGP DGVPQSTLLG 960
ILLPLLLLVA ALATALVFSY WWRRKQLVLP PNLNDLASLD QTAGATPLPI LYSGSDYRSG 1020
LALPAIDGLD STTCVHGASF SDSEDESCVP LLRKESIQLR DLDSALLAEV KDVLIPHERV 1080
VTHSDRVIGK GHFGVVYHGE YIDQAQNRIQ CAIKSLSRIT EMQQVEAFLR EGLLMRGLNH 1140
PNVLALIGIM LPPEGLPHVL LPYMCHGDLL QFIRSPQRNP TVKDLISFGL QVARSMEYLA 1200
EQKFVHRDLA ARNCMLDESF TVKVADFGLA RDILDREYYS VQQHRHARLP VKWMALESLQ 1260
TYRFTTKSDV WSFGVLLWEL LTRGAPPYRH IDPFDLTHFL AQGRRLPQPE YCPDSLYQVM 1320
QQCWEADPAV RPTFRVLVGE VEQIVSALLG DHYVQLPATY MNLGPSTSHE MNVRPEQPQF 1380
SPMPGNVRRP RPLSEPPRPT 1400 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0001725; C:stress fiber; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005011; F:macrophage colony-stimulating factor receptor activity; TAS:ProtInc. GO:0006928; P:cellular component movement; TAS:ProtInc. GO:0006952; P:defense response; TAS:ProtInc. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:InterPro. GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc. GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB. GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:UniProtKB. GO:0009615; P:response to virus; IDA:UniProtKB. GO:0007338; P:single fertilization; TAS:ProtInc. GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |