CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Mcm2 
Protein Synonyms/Alias
  
Gene Name
 Mcm2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
735AKERVRPKLNQMDQDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 905 AA 
Protein Sequence
MAESSESFSA ASSPAPQRRR ISDPLTSSPG RSSRRADALT SSPGRDLPPF EDESEGLLGT 60
EGPVEEEEDG EELIGDGMER DYRPIPELDV YEAEGLALDD EDVEELTASQ REAAERAMRQ 120
RDREAGRGLG RMRRGLLYDS DEEDEERPAR KRRHIERATE DGEEDEEMIE SIENLEDLKG 180
HSVREWVSMA GPRLEIHHRF KNFLRTHVDS HGHNVFKERI SDMCKENRES LVVNYEDLAA 240
REHVLAYFLP EAPAELLQIF DEAALEVVLA MYPKYDRITN HIHVRISHLP LVEELRSLRQ 300
LHLNQLIRTS GVVTSCTGVL PQLSMVKYNC SKCNFILGPF CQSQNQEVKP GSCPECQSTG 360
PFEINMEETI YQNYQRIRIQ ESPGKVAAGR LPRSKDAILL ADLVDSCKPG DEIELTGIYH 420
NNYDGSLNTT NGFPVFATII LANHVAKKDN KVAVGELTDE DVKMITSLSK DQQIGEKIFA 480
SIAPSIYGHE DIKRGLALAL FGGEPKNPGG KHKVRGDINV LLCGDPGTAK SQFLKYIEKV 540
SSRAIFTTGQ GASAVGLTAY VQRHPVSREW TLEAGALVLA DRGVCLIDEF DKMNDQDRTS 600
IHEAMEQQSI SISKAGIVTS LQARCTVIAA ANPIGGRYDP SLTFSENVDL TEPIISRFDV 660
LCVVRDTVDP VQDEMLARFV VGSHVRHHPS NKKDEGLTNG GTTEPAMPNT YGVEPLPQEV 720
LKKYIIYAKE RVRPKLNQMD QDKVARMYSD LRKESMATGS IPITVRHIES MIRMAEAHAR 780
MHLRDYVMED DVNMAIRVML ESFIDTQKFS VMRSMRKTFA RYLSFRRDNN DLLLFILKQL 840
VAEQVTYQRN RFGAQQDTIE IPEKDLMDKA RQINIHNLSA FYDSDLFKIN KFSRDLKRKL 900
ILQQF 905 
Gene Ontology
 GO:0000785; C:chromatin; IEA:Compara.
 GO:0042555; C:MCM complex; IEA:Compara.
 GO:0005664; C:nuclear origin of replication recognition complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003678; F:DNA helicase activity; IEA:InterPro.
 GO:0003688; F:DNA replication origin binding; IEA:Compara.
 GO:0006270; P:DNA replication initiation; IEA:InterPro.
 GO:0006268; P:DNA unwinding involved in replication; IEA:Compara.
 GO:0006334; P:nucleosome assembly; IEA:Compara. 
Interpro
 IPR008045; MCM2.
 IPR018525; MCM_CS.
 IPR001208; MCM_DNA-dep_ATPase.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00493; MCM
 PF12619; MCM2_N 
SMART
 SM00350; MCM 
PROSITE
 PS00847; MCM_1
 PS50051; MCM_2 
PRINTS
 PR01657; MCMFAMILY.
 PR01658; MCMPROTEIN2.