CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016949
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 COBW domain-containing protein 2 
Protein Synonyms/Alias
 Cobalamin synthase W domain-containing protein 2 
Gene Name
 CBWD2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41EKSGLGAKIPVTIITubiquitination[1, 2]
55TGYLGAGKTTLLNYIubiquitination[1]
69ILTEQHSKRVAVILNubiquitination[1, 2]
113GCLCCSVKDNGLRAIubiquitination[2]
126AIENLMQKKGKFDYIubiquitination[1]
127IENLMQKKGKFDYILubiquitination[2]
176VDSKYGLKHLAEEKPubiquitination[1, 2, 3]
182LKHLAEEKPDGLINEubiquitination[2]
204ADAILINKTDLVPEEubiquitination[1, 2]
214LVPEEDVKKLRATIRubiquitination[1, 2]
215VPEEDVKKLRATIRSubiquitination[2]
258LSGISLQKKLQHVPGubiquitination[1]
306WEKNVRNKDNHCMEVubiquitination[2]
317CMEVIRLKGLVSIKDubiquitination[2]
323LKGLVSIKDKSQQVIubiquitination[2]
325GLVSIKDKSQQVIVQubiquitination[1]
348EETPVSWKDDTERTNubiquitination[1, 2]
366LLGRNLDKDILKQLFubiquitination[2]
370NLDKDILKQLFIATVubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
 DOMAIN 274 377 CobW C-terminal.
 NP_BIND 49 56 ATP (Potential).
 NP_BIND 110 114 ATP (Potential).
 NP_BIND 203 206 ATP (Potential).  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MLPAVGSADE EEDPAEEDCP ELVPMETTQS EEEEKSGLGA KIPVTIITGY LGAGKTTLLN 60
YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW LELRNGCLCC SVKDNGLRAI 120
ENLMQKKGKF DYILLETTGL ADPGAVASMF WVDAELGSDI YLDGIITIVD SKYGLKHLAE 180
EKPDGLINEA TRQVALADAI LINKTDLVPE EDVKKLRATI RSINGLGQIL ETQRSRVDLS 240
NVLDLHAFDS LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE 300
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD TERTNRLVLL 360
GRNLDKDILK QLFIATVTET EKQWTTHFKE DQVCT 395 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 
Interpro
 IPR011629; Cbl_biosynth_CobW-like_C.
 IPR003495; CobW/HypB/UreG_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF02492; cobW
 PF07683; CobW_C 
SMART
 SM00833; CobW_C 
PROSITE
  
PRINTS