CPLM-008845

Genbank Nucleotide ID

Protein Synonyms/Alias

Spinocerebellar ataxia type 1 protein homolog

Mus musculus (Mouse)

Position	Peptide	Type	References
685	DPASVLLKQAKTDSL	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (By similarity). May be involved in RNA metabolism.

DOMAIN 538 669 AXH.
REGION 470 580 Self-association (By similarity).
REGION 514 791 Interaction with USP7 (By similarity).
REGION 516 742 RNA-binding (By similarity).
MOTIF 770 773 Nuclear localization signal.
MOD_RES 213 213 Phosphoserine (By similarity).
MOD_RES 751 751 Phosphoserine (By similarity).
CROSSLNK 16 16 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 193 193 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 585 585 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 672 672 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 721 721 Glycyl lysine isopeptide (Lys-Gly)

Complete proteome; Cytoplasm; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repressor; RNA-binding; Transcription; Transcription regulation; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0042405; C:nuclear inclusion body; ISS:UniProtKB.
GO:0016363; C:nuclear matrix; ISS:UniProtKB.
GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0034046; F:poly(G) RNA binding; ISS:UniProtKB.
GO:0008266; F:poly(U) RNA binding; ISS:UniProtKB.
GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
GO:0043621; F:protein self-association; ISS:UniProtKB.
GO:0008344; P:adult locomotory behavior; IMP:MGI.
GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IMP:MGI.
GO:0042326; P:negative regulation of phosphorylation; IMP:MGI.
GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
GO:0051168; P:nuclear export; ISS:UniProtKB.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IMP:MGI.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
GO:0008542; P:visual learning; IMP:MGI.

IPR013723; Ataxin-1_HBP1.
IPR003652; Ataxin_AXH_dom.
IPR020997; Capicua_tscrpt_rep_mod.

PF12547; ATXN-1_C
PF08517; AXH