CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043064
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sorbitol dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 SORD 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63EKVGSSVKHLKPGDRubiquitination[1]
86RENDEFCKMGRYNLSubiquitination[1, 2, 3, 4]
113GNLCRFYKHNAAFCYubiquitination[1]
205DLVLQISKESPQEIAubiquitination[5]
274AIREVDIKGVFRYCNubiquitination[1, 4]
298ASKSVNVKPLVTHRFubiquitination[5]
318LEAFETFKKGLGLKIubiquitination[5]
319EAFETFKKGLGLKIMubiquitination[1]
328LGLKIMLKCDPSDQNubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Oxidoreductase; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 336 AA 
Protein Sequence
MENYPIPEPG PNEVLLRMHS VGICGSDVHY WEYGRIGNFI VKKPMVLGHE ASGTVEKVGS 60
SVKHLKPGDR VAIEPGAPRE NDEFCKMGRY NLSPSIFFCA TPPDDGNLCR FYKHNAAFCY 120
KLPDNVTFEE GALIEPLSVG IHACRRGGVT LGHKVLVCGA GPIGMVTLLV AKAMGAAQVV 180
VTDLSATRLS KAKEIGADLV LQISKESPQE IARKVEGQLG CKPEVTIECT GAEASIQAGI 240
YATRSGGNLV LVGLGSEMTT VPLLHAAIRE VDIKGVFRYC NTWPVAISML ASKSVNVKPL 300
VTHRFPLEKA LEAFETFKKG LGLKIMLKCD PSDQNP 336 
Gene Ontology
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF08240; ADH_N
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
 PS00059; ADH_ZINC 
PRINTS