CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043682
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear receptor ROR-gamma 
Protein Synonyms/Alias
  
Gene Name
 RORC 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
156GMSRDAVKFGRMSKKubiquitination[1]
333HLVQSVCKSYRETCQubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
MWGTGPSAGK DRMSGRPWPH PWSKSGTPSE QDRRATGLVS CEHGGGKFEG QSHQAPGPPG 60
GGRTGCLELL AAKKTHTSQI EVIPCKICGD KSSGIHYGVI TCEGCKGFFR RSQRCNAAYS 120
CTRQQNCPID RTSRNRCQHC RLQKCLALGM SRDAVKFGRM SKKQRDSLHA EVQKQLQQRQ 180
QQQQEPVVKT PPAGAQGADT LTYTLGLPDG QLPLGSSPDL PEASACPPGL LKASGSGPSY 240
SNNLAKAGLN GASCHLEYSP ERGKAEGRES FYSTGSQLTP DRCGLRFEEH RHPGLGELGQ 300
GPDSYGSPSF RSTPEAPYAS LTEIEHLVQS VCKSYRETCQ LRLEDLLRQR SNIFSREEVT 360
GYQRKSMWEM WERCAHHLTE AIQYVVEFAK RLSGFMELCQ NDQIVLLKAG AMEVVLVRMC 420
RAYNADNRTV FFEGKYGGME LFRALGCSEL ISSIFDFSHS LSALHFSEDE IALYTALVLI 480
NAHRPGLQEK RKVEQLQYNL ELAFHHHLCK THRQSILAKL PPKGKLRSLC SQHVERLQIF 540
QHLHPIVVQA AFPPLYKELF STETESPVGL SK 572 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:InterPro.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030522; P:intracellular receptor signaling pathway; IEA:GOC. 
Interpro
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR003079; ROR_rcpt.
 IPR001723; Str_hrmn_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR01293; RORNUCRECPTR.
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.