CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029125
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin fusion degradation protein 1 homolog 
Protein Synonyms/Alias
  
Gene Name
 UFD1L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
57ITYPMLFKLTNKNSDubiquitination[1, 2, 3]
61MLFKLTNKNSDRMTHubiquitination[4, 5]
128FLDITNPKAVLENALubiquitination[1, 2, 3, 4, 6]
164ELRVMETKPDKAVSIubiquitination[1, 4, 5]
167VMETKPDKAVSIIECubiquitination[1, 5]
187FDAPLGYKEPERQVQubiquitination[1]
239EPSPSPIKPGDIKRGubiquitination[2, 6]
244PIKPGDIKRGIPNYEubiquitination[2, 6]
253GIPNYEFKLGKITFIubiquitination[2, 3, 5, 6, 7]
256NYEFKLGKITFIRNSubiquitination[2, 6, 7]
268RNSRPLVKKVEEDEAubiquitination[3, 4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 296 AA 
Protein Sequence
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKSRLNI TYPMLFKLTN 60
KNSDRMTHCG VLEFVADEGI CYLPHWMMQN LLLEEGGLVQ VESVNLQVAT YSKFQPQSPD 120
FLDITNPKAV LENALRNFAC LTTGDVIAIN YNEKIYELRV METKPDKAVS IIECDMNVDF 180
DAPLGYKEPE RQVQHEESTE GEADHSGYAG ELGFRAFSGS GNRLDGKKKG VEPSPSPIKP 240
GDIKRGIPNY EFKLGKITFI RNSRPLVKKV EEDEAGGRFV AFSGEGQSLR KKGRKP 296 
Gene Ontology
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR004854; UFD1. 
Pfam
 PF03152; UFD1 
SMART
  
PROSITE
  
PRINTS