| Tag | Content |
|---|
| CPLM ID | CPLM-001438 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-actinin-3 |
Protein Synonyms/Alias | Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein |
Gene Name | Actn3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 108 | HKIANVNKALDFIAS | ubiquitination | [1] | | 211 | IDYAKLRKDDPIGNL | ubiquitination | [1] | | 277 | TAANRICKVLAVNQE | ubiquitination | [1] | | 287 | AVNQENEKLMEEYEK | ubiquitination | [1] | | 411 | RLQHLAEKFQQKASL | ubiquitination | [1] | | 415 | LAEKFQQKASLHEAW | ubiquitination | [1] | | 426 | HEAWTRGKEEMLNQH | ubiquitination | [1] | | 616 | SSQDINNKWDTVRKL | ubiquitination | [1] | | 622 | NKWDTVRKLVPSRDQ | ubiquitination | [1] | | 754 | QVLTRDAKGLSQEQL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). |
Sequence Annotation | DOMAIN 1 260 Actin-binding.
DOMAIN 44 148 CH 1.
DOMAIN 157 260 CH 2.
REPEAT 287 397 Spectrin 1.
REPEAT 407 512 Spectrin 2.
REPEAT 522 633 Spectrin 3.
REPEAT 643 746 Spectrin 4.
DOMAIN 759 794 EF-hand 1.
DOMAIN 795 830 EF-hand 2. |
Keyword | Actin-binding; Calcium; Complete proteome; Metal-binding; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 900 AA |
Protein Sequence | MMMVMQPEGL GAGEGPFSGG GGGEYMEQEE DWDRDLLLDP AWEKQQRKTF TAWCNSHLRK 60
AGTQIENIEE DFRNGLKLML LLEVISGERL PRPDKGKMRF HKIANVNKAL DFIASKGVKL 120
VSIGAEEIVD GNLKMTLGMI WTIILRFAIQ DISVEETSAK EGLLLWCQRK TAPYRNVNVQ 180
NFHTSWKDGL ALCALIHRHR PDLIDYAKLR KDDPIGNLNT AFEVAEKYLD IPKMLDAEDI 240
VNTPKPDEKA IMTYVSCFYH AFAGAEQAET AANRICKVLA VNQENEKLME EYEKLASELL 300
EWIRRTVPWL ENRVGEPSMS AMQRKLEDFR DYRRLHKPPR VQEKCQLEIN FNTLQTKLRL 360
SHRPAFMPSE GKLVSDIANA WRGLEQVEKG YEDWLLSEIR RLQRLQHLAE KFQQKASLHE 420
AWTRGKEEML NQHDYESASL QEVRALLRRH EAFESDLAAH QDRVEHIAAL AQELNELDYH 480
EAASVNSRCQ AICDQWDNLG TLTQKRRDAL ERMEKLLETI DQLQLEFARR AAPFNNWLDG 540
AIEDLQDVWL VHSVEETQSL LTAHEQFKAT LPEADRERGA ILGIQGEIQK ICQTYGLRPK 600
SGNPYITLSS QDINNKWDTV RKLVPSRDQT LQEELARQQV NERLRRQFAA QANAIGPWIQ 660
GKVEEVGRLA AGLAGSLEEQ MAGLRQQEQN IINYKSNIDR LEGDHQLLQE SLVFDNKHTV 720
YSMEHIRVGW EQLLTSIART INEVENQVLT RDAKGLSQEQ LNEFRASFNH FDRKRNGMME 780
PDDFRACLIS MGYDLGEVEF ARIMTMVDPN AAGVVTFQAF IDFMTRETAE TDTAEQVVAS 840
FKILAGDKNY ITPEELRREL PAEQAEYCIR RMAPYKGSGA PSGALDYVAF SSALYGESDL 900 |
Gene Ontology | GO:0005865; C:striated muscle thin filament; TAS:MGI. GO:0030018; C:Z disc; IDA:MGI. GO:0051015; F:actin filament binding; IDA:MGI. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0030674; F:protein binding, bridging; TAS:MGI. GO:0042803; F:protein homodimerization activity; TAS:UniProtKB. GO:0051764; P:actin crosslink formation; IEA:InterPro. GO:0051017; P:actin filament bundle assembly; IEA:InterPro. GO:0006936; P:muscle contraction; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |