UniProt Accession

 BL1S2_RAT; Q32WR5 

Genbank Protein ID

 AY786315 

Genbank Nucleotide ID

 AAX11391.1 

Protein Name

 Biogenesis of lysosome-related organelles complex-1 subunit 2 

Protein Synonyms/Alias

 BLOC-1 subunit 2; Spinal cord-expressed protein 1 

Gene Name

 Bloc1s2 

Gene Synonyms/Alias

 Rsep1; Sep1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
135	YSKKLEAKYKKLEKR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in cell proliferation (By similarity). May be a mediator in the mechanisms of neuropathic pain. 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
 GO:0005813; C:centrosome; IDA:RGD.
 GO:0000930; C:gamma-tubulin complex; IEA:Compara.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0055037; C:recycling endosome; IDA:RGD.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; ISS:UniProtKB.
 GO:0097345; P:mitochondrial outer membrane permeabilization; ISS:UniProtKB.
 GO:0031175; P:neuron projection development; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:RGD.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara. 

Interpro

 IPR019269; BLOC1_su2. 

Pfam

 PF10046; BLOC1_2 

SMART

  

PROSITE

  

PRINTS