CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014236
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bile acid receptor 
Protein Synonyms/Alias
 Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14 
Gene Name
 Nr1h4 
Gene Synonyms/Alias
 Bar; Fxr; Rip14 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
370LLEERIRKSGISDEYubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). 
Sequence Annotation
 DNA_BIND 135 210 Nuclear receptor.
 ZN_FING 138 158 NR C4-type.
 ZN_FING 174 198 NR C4-type.
 REGION 258 476 Ligand-binding (By similarity).
 REGION 344 352 Agonist binding (By similarity).
 BINDING 377 377 Agonist (By similarity).
 BINDING 385 385 Agonist (By similarity).
 BINDING 463 463 Agonist (By similarity).
 BINDING 485 485 Agonist (By similarity).
 MOD_RES 221 221 N6-methyllysine; by SETD7 (By  
Keyword
 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Methylation; Nucleus; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 488 AA 
Protein Sequence
MVMQFQGLEN PIQISLHHSH RLSGFVPEGM SVKPAKGMLT EHAAGPLGQN LDLESYSPYN 60
NVPFPQVQPQ ISSSSYYSNL GFYPQQPEDW YSPGIYELRR MPAETGYQGE TEVSEMPVTK 120
KPRMAAASAG RIKGDELCVV CGDRASGYHY NALTCEGCKG FFRRSITKNA VYKCKNGGNC 180
VMDMYMRRKC QECRLRKCKE MGMLAECMYT GLLTEIQCKS KRLRKNVKQH ADQTANEDDS 240
EGRDLRQVTS TTKFCREKTE LTADQQTLLD YIMDSYNKQR MPQEITNKIL KEEFSAEENF 300
LILTEMATSH VQILVEFTKK LPGFQTLDHE DQIALLKGSA VEAMFLRSAE IFNKKLPAGH 360
ADLLEERIRK SGISDEYITP MFSFYKSVGE LKMTQEEYAL LTAIVILSPD RQYIKDREAV 420
EKLQEPLLDV LQKLCKMYQP ENPQHFACLL GRLTELRTFN HHHAEMLMSW RVNDHKFTPL 480
LCEIWDVQ 488 
Gene Ontology
 GO:0005719; C:nuclear euchromatin; IEA:Compara.
 GO:0032052; F:bile acid binding; IMP:BHF-UCL.
 GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; IMP:BHF-UCL.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0046965; F:retinoid X receptor binding; IDA:MGI.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0001190; F:RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0003707; F:steroid hormone receptor activity; IEA:Compara.
 GO:0004887; F:thyroid hormone receptor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008206; P:bile acid metabolic process; IMP:MGI.
 GO:0071229; P:cellular response to acid; IMP:BHF-UCL.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0001080; P:nitrogen catabolite activation of transcription from RNA polymerase II promoter; IC:BHF-UCL.
 GO:2001250; P:positive regulation of ammonia assimilation cycle; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0006109; P:regulation of carbohydrate metabolic process; IEA:Compara.
 GO:0034255; P:regulation of urea metabolic process; IMP:BHF-UCL.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara. 
Interpro
 IPR008946; Nucl_hormone_rcpt_ligand-bd.
 IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
 IPR001723; Str_hrmn_rcpt.
 IPR001728; ThyrH_rcpt.
 IPR001628; Znf_hrmn_rcpt.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00104; Hormone_recep
 PF00105; zf-C4 
SMART
 SM00430; HOLI
 SM00399; ZnF_C4 
PROSITE
 PS00031; NUCLEAR_REC_DBD_1
 PS51030; NUCLEAR_REC_DBD_2 
PRINTS
 PR00398; STRDHORMONER.
 PR00047; STROIDFINGER.
 PR00546; THYROIDHORMR.