CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007379
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATF/CREB activator 2 
Protein Synonyms/Alias
 Chromosome stability protein CST6 
Gene Name
 CST6 
Gene Synonyms/Alias
 ACA2; YIL036W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
178SQLSSTRKSAPNDSTubiquitination[1]
349DQSVIYSKSQQRNFVacetylation[2]
349DQSVIYSKSQQRNFVubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources. 
Sequence Annotation
 DOMAIN 425 488 bZIP.
 REGION 427 447 Basic motif (By similarity).
 REGION 453 467 Leucine-zipper (By similarity).
 MOD_RES 171 171 Phosphoserine.
 MOD_RES 179 179 Phosphoserine.
 MOD_RES 557 557 Phosphoserine.
 MOD_RES 559 559 Phosphothreonine.  
Keyword
 Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 587 AA 
Protein Sequence
MFTGQEYHSV DSNSNKQKDN NKRGIDDTSK ILNNKIPHSV SDTSAAATTT STMNNSALSR 60
SLDPTDINYS TNMAGVVDQI HDYTTSNRNS LTPQYSIAAG NVNSHDRVVK PSANSNYQQA 120
AYLRQQQQQD QRQQSPSMKT EEESQLYGDI LMNSGVVQDM HQNLATHTNL SQLSSTRKSA 180
PNDSTTAPTN ASNIANTASV NKQMYFMNMN MNNNPHALND PSILETLSPF FQPFGVDVAH 240
LPMTNPPIFQ SSLPGCDEPI RRRRISISNG QISQLGEDIE TLENLHNTQP PPMPNFHNYN 300
GLSQTRNVSN KPVFNQAVPV SSIPQYNAKK VINPTKDSAL GDQSVIYSKS QQRNFVNAPS 360
KNTPAESISD LEGMTTFAPT TGGENRGKSA LRESHSNPSF TPKSQGSHLN LAANTQGNPI 420
PGTTAWKRAR LLERNRIAAS KCRQRKKVAQ LQLQKEFNEI KDENRILLKK LNYYEKLISK 480
FKKFSKIHLR EHEKLNKDSD NNVNGTNSSN KNESMTVDSL KIIEELLMID SDVTEVDKDT 540
GKIIAIKHEP YSQRFGSDTD DDDIDLKPVE GGKDPDNQSL PNSEKIK 587 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:SGD.
 GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
 GO:0071244; P:cellular response to carbon dioxide; IMP:SGD.
 GO:0071400; P:cellular response to oleic acid; IMP:SGD.
 GO:0006259; P:DNA metabolic process; IMP:SGD.
 GO:0061429; P:positive regulation of transcription from RNA polymerase II promoter by oleic acid; IMP:SGD. 
Interpro
 IPR004827; bZIP. 
Pfam
 PF00170; bZIP_1 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS