Tag | Content |
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CPLM ID | CPLM-020623 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Biogenesis of lysosome-related organelles complex 1 subunit 2 |
Protein Synonyms/Alias | BLOC-1 subunit 2 |
Gene Name | Bloc1s2 |
Gene Synonyms/Alias | Blos2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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77 | MNKLTSLKYLEMKDI | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in cell proliferation. |
Sequence Annotation | |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 143 AA |
Protein Sequence | MAAAAEGVPA TRREEQPPRD DAAVETAEEA KEPAEADINE LCRDMFSKMA TYLTGELTAT 60 SEDYKLLENM NKLTSLKYLE MKDIAINISR NLKDLNQKYA ELQPYLDQIN MIEEQVAALE 120 QAAYKLDAYS KKLEAKYKKL EKR 143 |
Gene Ontology | GO:0031083; C:BLOC-1 complex; ISS:UniProtKB. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; ISS:UniProtKB. GO:0008089; P:anterograde axon cargo transport; IMP:UniProtKB. GO:0048490; P:anterograde synaptic vesicle transport; IMP:UniProtKB. GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; ISS:UniProtKB. GO:0097345; P:mitochondrial outer membrane permeabilization; ISS:UniProtKB. GO:0031175; P:neuron projection development; NAS:UniProtKB. |
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PRINTS | |