CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002781
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription factor jun-B 
Protein Synonyms/Alias
 MyD21 
Gene Name
 Junb 
Gene Synonyms/Alias
 Jun-b 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
36LHDYKLLKPTLALNLacetylation[1, 2]
237SRGASAFKEEPQTVPacetylation[1, 2, 3]
237SRGASAFKEEPQTVPsumoylation[4]
267MEDQERIKVERKRLRsumoylation[4]
301EDKVKTLKAENAGLSsumoylation[4]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SUMOylation regulates the transcriptional activity of JunB in T lymphocytes.
 Garaude J, Farrás R, Bossis G, Charni S, Piechaczyk M, Hipskind RA, Villalba M.
 J Immunol. 2008 May 1;180(9):5983-90. [PMID: 18424718] 
Functional Description
 Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. 
Sequence Annotation
 DOMAIN 265 328 bZIP.
 REGION 265 292 Basic motif (By similarity).
 REGION 293 321 Leucine-zipper (By similarity).
 MOD_RES 102 102 Phosphothreonine (By similarity).
 MOD_RES 104 104 Phosphothreonine (By similarity).
 MOD_RES 117 117 Phosphoserine (By similarity).
 MOD_RES 248 248 Phosphoserine.
 MOD_RES 252 252 Phosphothreonine.
 MOD_RES 256 256 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 344 AA 
Protein Sequence
MCTKMEQPFY HDDSYAAAGY GRSPGSLSLH DYKLLKPTLA LNLADPYRGL KGPGARGPGP 60
EGSGAGSYFS GQGSDTGASL KLASTELERL IVPNSNGVIT TTPTPPGQYF YPRGGGSGGG 120
TGGGVTEEQE GFADGFVKAL DDLHKMNHVT PPNVSLGASG GPQAGPGGVY AGPEPPPVYT 180
NLSSYSPASA PSGGSGTAVG TGSSYPTATI SYLPHAPPFA GGHPAQLGLS RGASAFKEEP 240
QTVPEARSRD ATPPVSPINM EDQERIKVER KRLRNRLAAT KCRKRKLERI ARLEDKVKTL 300
KAENAGLSSA AGLLREQVAQ LKQKVMTHVS NGCQLLLGVK GHAF 344 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0071277; P:cellular response to calcium ion; IDA:MGI.
 GO:0032870; P:cellular response to hormone stimulus; IEA:Compara.
 GO:0046697; P:decidualization; IMP:MGI.
 GO:0060136; P:embryonic process involved in female pregnancy; IMP:MGI.
 GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI.
 GO:0001649; P:osteoblast differentiation; IMP:MGI.
 GO:0033687; P:osteoblast proliferation; IMP:MGI.
 GO:0030316; P:osteoclast differentiation; IMP:MGI.
 GO:0045597; P:positive regulation of cell differentiation; IDA:MGI.
 GO:0051726; P:regulation of cell cycle; IDA:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0051412; P:response to corticosterone stimulus; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0009416; P:response to light stimulus; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0001829; P:trophectodermal cell differentiation; IDA:MGI.
 GO:0001570; P:vasculogenesis; IMP:MGI. 
Interpro
 IPR004827; bZIP.
 IPR008917; Euk_TF_DNA-bd.
 IPR005643; JNK.
 IPR002112; Leuzip_Jun. 
Pfam
 PF00170; bZIP_1
 PF03957; Jun 
SMART
 SM00338; BRLZ 
PROSITE
 PS50217; BZIP
 PS00036; BZIP_BASIC 
PRINTS
 PR00043; LEUZIPPRJUN.