UniProt Accession

 AL3A1_HUMAN; P30838; A8K828; Q9BT37 

Genbank Protein ID

 M74542; M77477; S61044; BT007102; AK292193; AK314584; AC005722; CH471212; BC004370; BC008892; BC021194 

Genbank Nucleotide ID

 AAA51696.1; AAB46377.1; AAB26658.1; AAP35766.1; BAF84882.1; BAG37160.1; EAW50909.1; AAH04370.1; AAH08892.1; AAH21194.1 

Protein Name

 Aldehyde dehydrogenase, dimeric NADP-preferring 

Protein Synonyms/Alias

 ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1 

Gene Name

 ALDH3A1 

Gene Synonyms/Alias

 ALDH3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
3	*****MSKISEAVKR	acetylation	[1]
178	PETTELLKERFDHIL	acetylation	[1]
194	TGSTGVGKIIMTAAA	acetylation	[1]
269	EKLKKSLKEFYGEDA	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. 

Sequence Annotation

 NP_BIND 188 193 NAD or NADP (By similarity).
 ACT_SITE 210 210
 ACT_SITE 244 244
 MOD_RES 178 178 N6-acetyllysine.
 MOD_RES 194 194 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; NADP; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 453 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
 GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; IEA:Compara.
 GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IDA:UniProtKB.
 GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IDA:UniProtKB.
 GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IEA:EC.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006081; P:cellular aldehyde metabolic process; IDA:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0051591; P:response to cAMP; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR012394; Aldehyde_DH_NAD(P). 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 

PRINTS