UniProt Accession

 SLT2_YEAST; Q00772; D3DKX7 

Genbank Protein ID

 X59262; U00062; BK006934 

Genbank Nucleotide ID

 CAA41954.1; AAB68912.1; DAA06721.1 

Protein Name

 Mitogen-activated protein kinase SLT2/MPK1 

Protein Synonyms/Alias

 MAP kinase MPK1 

Gene Name

 SLT2 

Gene Synonyms/Alias

 MPK1; YHR030C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
155	DVLHRDLKPGNLLVN	ubiquitination	[1]
263	TLRRIGSKNVQDYIH	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Serine/threonine protein kinase involved in a signal transduction pathway that play a role in yeast cell morphogenesis and cell growth. This pathway seems to start by SMP3; then involve the kinase PKC1 that may act the BCK1 kinase that then phosphorylates MKK1 and MKK2 which themselves phosphorylate the SLT2/MPK1 kinase which itself then phosphorylates and activates the transcription factor RLM1. Directly phosphorylates BCY1 upon TOR complex 1 (TORC1) inhibition. 

Sequence Annotation

 DOMAIN 23 318 Protein kinase.
 NP_BIND 29 37 ATP (By similarity).
 MOTIF 190 192 TXY.
 ACT_SITE 153 153 Proton acceptor (By similarity).
 BINDING 54 54 ATP (By similarity).
 MOD_RES 190 190 Phosphothreonine.
 MOD_RES 192 192 Phosphotyrosine.  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 484 AA 

Protein Sequence

Gene Ontology

 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004707; F:MAP kinase activity; ISS:SGD.
 GO:0000917; P:barrier septum assembly; IGI:SGD.
 GO:0009272; P:fungal-type cell wall biogenesis; IGI:SGD.
 GO:0030242; P:peroxisome degradation; IMP:SGD.
 GO:0008361; P:regulation of cell size; IMP:SGD.
 GO:0060237; P:regulation of fungal-type cell wall organization; IMP:SGD.
 GO:0042990; P:regulation of transcription factor import into nucleus; IMP:SGD.
 GO:0001101; P:response to acid; IMP:SGD.
 GO:0030969; P:UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response; IMP:SGD. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR003527; MAP_kinase_CS.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS01351; MAPK
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS