| Tag | Content |
|---|
| CPLM ID | CPLM-016846 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 29 |
Protein Synonyms/Alias | Rho-type GTPase-activating protein 29 |
Gene Name | Arhgap29 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 46 | SFDPEYIKELVNDVR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis. |
Sequence Annotation | DOMAIN 673 888 Rho-GAP.
ZN_FING 614 659 Phorbol-ester/DAG-type.
REGION 1263 1266 Interaction with PTPN13/PTPL1 (By
MOD_RES 171 171 Phosphoserine.
MOD_RES 176 176 Phosphoserine.
MOD_RES 179 179 Phosphoserine.
MOD_RES 190 190 Phosphoserine (By similarity).
MOD_RES 956 956 Phosphoserine (By similarity).
MOD_RES 1028 1028 Phosphoserine (By similarity).
MOD_RES 1151 1151 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Coiled coil; Complete proteome; GTPase activation; Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1266 AA |
Protein Sequence | MIAHKQKKAK KKRVWASGQP SAAITTSEMG LKSVSSSSSF DPEYIKELVN DVRKFSHMLL 60
YLKEAILSDC FKEVIHIRLD ELLRVLKSIL SKHQNLSSVD LQSAAEVLTA KVKAVNFTEV 120
NEENKNDIFR EVFSSIETLA FTFGNILTNF LMGDVGSDSI LRLPISRESK SFENISVDSV 180
DLPHEKGNFS PIELDNLLLK NTDSIELALS YAKTWSKYTK NIVSWVEKKL NLELESTRNI 240
VKLAEATRSS IGIQEFMPLQ SLFTNALLSD IHSSHLLQQT IAALQANKFV QPLLGRKNEM 300
EKQRKEIKDL WKQQQNKLLE TETALKKAKL LCMQRQDEYE KAKSSMFRAE EEQLSSSVGL 360
AKNLNKQLEK RRRLEEEALQ KVEEANEHYK VCVTNVEERR NDLENTKREI LTQLRTLVFQ 420
CDLTLKAVTV NLFHMQQLQA ASLANSLQSL CDSAKLYDPG QEYSEFVKAT SSSELEEKVD 480
GNVNKQMTNS PQTSGYEPAD SLEDVARLPD SCHKLEEDRC SNSADMTGPS FVRSWKFGMF 540
SDSESTGGSS ESRSLDSESI SPGDFHRKLP RTPSSGTMSS ADDLDEREPP SPSEAGPNSL 600
GAFKKTLMSK AALTHKFRKL RSPTKCRDCD GIVMFPGVEC EECLLVCHRK CLENLVIICG 660
HQKLQGKMHI FGAEFIQVAK KEPDGIPFVL KICASEIENR ALCLQGIYRV CGNKIKTEKL 720
CQALENGMHL VDISEFSSHD ICDVLKLYLR QLPEPFILFR LYKEFIDLAK EIQHVNEEQE 780
AKKDSPEDKK HPHVSIEVNR ILLKSKDLLR QLPASHFNSL HYLIAHLRRV VDHAEENKMN 840
SKNLGVIFGP TLIRPRPTTA PVTISSLAEY SNQARLVEFL ITYSQKIFDG SLQPQAVVIS 900
NTGAVAPQVD QGYLPKPLLS PDERDTDHSM KPLFFSSKED IRSSDCESKS FELTTSFEES 960
ERRQNALGKC DAPLLDNKVH LLFDQEHESA SQKMEDVCKS PKLLLLKSNR AANSVQRHTP 1020
RTKMRPVSLP VDRLLLLASS PTERSSRDVG NVDSDKFGKN PAFEGLHRKD NSNTTRSKVN 1080
GFDQQNVQKS WDTQYVRNNF TAKTTMIVPS AYPEKGLTVN TGNNRDHPGS KAHAEPARAA 1140
GDVSERRSSD SCPATAVRAP RTLQPQHWTT FYKPPNPTFS VRGTEEKTAL PSIAVPPVLV 1200
HAPQIHVTKS DPDSEATLAC PVQTSGQPKE SSEEPALPEG TPTCQRPRLK RMQQFEDLED 1260
EIPQFV 1266 |
Gene Ontology | GO:0005622; C:intracellular; IEA:InterPro. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0035556; P:intracellular signal transduction; IEA:InterPro. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |