CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030020
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Scn7a 
Protein Synonyms/Alias
  
Gene Name
 Scn7a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
27LIENHIAKKCNEDPEubiquitination[1]
28IENHIAKKCNEDPEEubiquitination[1]
77VDPYYYVKRNTFMVLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1681 AA 
Protein Sequence
MLTSPEPKGL VPFTTESLEL IENHIAKKCN EDPEEEEGLK PSRNLEAGKR LPIPYGTLPR 60
GTVSEPLEDV DPYYYVKRNT FMVLNRSRVI FRFNAVSIFC TLSPLNSLRR AAIKALVHPL 120
FRLLILISVL TDSILMCMSN LPEWILAIEN TLLGIYAFEI LVKVIARGIW AGSFSFLGDL 180
WNWLDFSVTL FELITRFSPL SSFLMLKTIR TFRILKIIPL NHGLQSIVMT LAQCLKKLFG 240
AIALALFFLA VFSLLGMGLF MGNLKHKCLR WPEENENETL HNRTGSLNYS PERINFYYME 300
GAKYALLCGN RTDAGQCPEG YVCVKEGTNP DNGFTSFDNF GWSLLAMFRL MTQDYPELLY 360
HQILYASGKV YMIFFVMISF WFAFYLTSLF LGILTMTYEK EKQRACEESG GLDPKCQQTV 420
KELDEENDAA EMETTQIEMK KRSPTSINTT LDILEDTTLG HREEPETSRK KCPICWHKFI 480
KTCFIWKCSP CWVKLNEFAD RVITHPLADL FLVICIVLNI CFLALEHFPM SEELRSLLHV 540
GNLVFIGIYT IEMILKIIAM HPYGYFQISW NIFDSILVVL ELTEILLADV EGLAVLITVP 600
LIFIKLGKYG PPFKSLMRIL GSSLMALKDL VLLLCIFVYF SAVFGMKLFG RSYKDCVCHI 660
KEDCQPQRWH MSDFLHAYMT VFRILCGEWI ETLWECMEVA GQAWCIPFYM MVILIGNLLI 720
LYLFVTLVSS FSYYDATSEV NKEAKNLQLA MARIKSGINS MLLKLMCTER SVPTEATDQI 780
CDPSVKENIS GHTLSELSNT QTFLRYKDQS SSTEKTPVTE SESQSLIASP SASETVPIAS 840
GESDIENLDN KETRSKSGNG GSKEKMKQSS SSECSTVDIA ISEEEEMVYE HEKSKLHKNG 900
YERKSSTGQI SRESRNGKIW KNIRKTCCKI VENSWFECFI GLVTLLCTGT LALEDIYIDQ 960
RKTTKILLEY ADMIFAYIFI LEMLLKWVAY GFKAFFSNNW YKLDFMVVIV FCLSLIGKTR 1020
EDLNPLTSIK FLRALRVLSQ FERMKVVLRA LIKTTLPTVS VFLVCLMIWL LFSVIGVQLF 1080
AGKFYECIDP TKGERFPVFE VMNKSQCEKL LFNESMPWEN AKLNFDNVGN GFLSLLQVAT 1140
FNGWISIMNS AIDSVGVNMQ PSFEYNLYMY SYFIIFVIFG LFLPLCMLIG VIIRNFNKQK 1200
IKQGGSNIFI TVKQKKQYRA LKKLLYADVQ KPTPRPRNKF QGFLFDLVTH RVFNVIIILL 1260
ICFQATTIMI QKDEQSPQME TAIFWMNSIF VMLFTLECIL KLTAFRCHYF TSAWNVHDFM 1320
VVIFSITGLL LPLTIGQYFV PPSLVQLILL SRVIHILRPG KGPKVFHDLM LPLILALPAL 1380
LNISLLIFLV MFIYAIFGMY NFAYVKKEAG INDVSNFETF GSSMLCLFQV TTFSGWDGML 1440
DAIFNSQWSD CDPDKINPGT QVKGDCGSPS VGISYFVSYI LISWLIIVNM YIVLIMEFLS 1500
IPSQKKSRTL SEDDFRRFFR VWNRFDPDRT QYIDSSKLSD FAAALDPPLF MAKPNKGQLV 1560
AMDLPMAAGD RIHCLDILLA FTKRVMGKDE RVEKILSEIE SGFMLANPFK ITYEPITTTL 1620
KRKQEAVSAT IIQRAYKSYR LRQNDKNVSD TPAIDDRRDD LTSKGAHSGK IEEKASIQTQ 1680
I 1681 
Gene Ontology
 GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
 GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 
Interpro
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
  
PRINTS
 PR00170; NACHANNEL.