UniProt Accession

 VDAC3_HUMAN; Q9Y277; Q9UIS0 

Genbank Protein ID

 U90943; AF038962; BC056870; AH008073 

Genbank Nucleotide ID

 AAB93872.1; AAC39876.1; AAH56870.1; AAD49610.1 

Protein Name

 Voltage-dependent anion-selective channel protein 3 

Protein Synonyms/Alias

 VDAC-3; hVDAC3; Outer mitochondrial membrane protein porin 3 

Gene Name

 VDAC3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	PTYCDLGKAAKDVFN	acetylation	[1]
20	AAKDVFNKGYGFGMV	acetylation	[1]
20	AAKDVFNKGYGFGMV	ubiquitination	[2, 3, 4, 5, 6]
28	GYGFGMVKIDLKTKS	acetylation	[1, 7]
28	GYGFGMVKIDLKTKS	ubiquitination	[3]
53	HAYTDTGKASGNLET	ubiquitination	[4, 6]
61	ASGNLETKYKVCNYG	acetylation	[1, 8]
63	GNLETKYKVCNYGLT	acetylation	[1]
90	TEISWENKLAEGLKL	acetylation	[1, 8]
109	IFVPNTGKKSGKLKA	ubiquitination	[4, 6]
110	FVPNTGKKSGKLKAS	ubiquitination	[3]
163	SFDTAKSKLSQNNFA	ubiquitination	[3, 4, 6]
266	LSALIDGKNFSAGGH	ubiquitination	[3, 6]
274	NFSAGGHKVGLGFEL	ubiquitination	[3, 4, 6]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [8] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

 Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). 

Sequence Annotation

 NP_BIND 242 244 NAD (By similarity).
 NP_BIND 260 264 NAD (By similarity).
 MOD_RES 2 2 N-acetylcysteine.
 MOD_RES 20 20 N6-acetyllysine.
 MOD_RES 48 48 Phosphotyrosine (By similarity).
 MOD_RES 90 90 N6-acetyllysine.
 MOD_RES 241 241 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Ion transport; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Nucleotide-binding; Phosphoprotein; Porin; Reference proteome; Transmembrane; Transmembrane beta strand; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 283 AA 

Protein Sequence

Gene Ontology

 GO:0005741; C:mitochondrial outer membrane; TAS:ProtInc.
 GO:0046930; C:pore complex; IEA:UniProtKB-KW.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0015288; F:porin activity; IEA:UniProtKB-KW.
 GO:0008308; F:voltage-gated anion channel activity; TAS:UniProtKB.
 GO:0015853; P:adenine transport; TAS:ProtInc. 

Interpro

 IPR023614; Porin_dom.
 IPR001925; Porin_Euk.
 IPR027246; Porin_Euk/Tom40. 

Pfam

 PF01459; Porin_3 

SMART

  

PROSITE

 PS00558; EUKARYOTIC_PORIN 

PRINTS

 PR00185; EUKARYTPORIN.