UniProt Accession

 VL2_HPV16; P03107; Q71BI1 

Genbank Protein ID

 K02718; AF536179 

Genbank Nucleotide ID

 AAA46942.1; AAQ10718.1 

Protein Name

 Minor capsid protein L2 

Protein Synonyms/Alias

  

Gene Name

 L2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Human papillomavirus type 16 

NCBI Taxa ID

 333760 

Lysine Modification

Position	Peptide	Type	References
35	CPPDIIPKVEGKTIA	sumoylation	[1]

Reference

 [1] Modification of human papillomavirus minor capsid protein L2 by sumoylation.
 Marusic MB, Mencin N, Licen M, Banks L, Grm HS.
 J Virol. 2010 Nov;84(21):11585-9. [PMID: 20739540] 

Functional Description

 Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA. 

Sequence Annotation

 MOTIF 1 13 Nuclear localization signal (Probable).
 MOTIF 454 462 Nuclear localization signal (Probable).
 DISULFID 22 28  

Keyword

 Capsid protein; Complete proteome; Cytoplasmic inwards viral transport; Disulfide bond; DNA-binding; Host nucleus; Host-virus interaction; Late protein; Microtubular inwards viral transport; Phosphoprotein; Reference proteome; Viral penetration into host nucleus; Virion; Virus entry into host cell. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 473 AA 

Protein Sequence

Gene Ontology

 GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
 GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0075521; P:microtubule-dependent intracellular transport of viral material to nucleus; IEA:UniProtKB-KW.
 GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
 GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW. 

Interpro

 IPR000784; Late_L2. 

Pfam

 PF00513; Late_protein_L2 

SMART

  

PROSITE

  

PRINTS