CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041740
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Lrp1 
Protein Synonyms/Alias
 RCG59548 
Gene Name
 Lrp1 
Gene Synonyms/Alias
 rCG_59548 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
2076WCDARMDKIERIDLEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; EGF-like domain; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4545 AA 
Protein Sequence
MLTPPLLLLL PLLSALVAGA TMDAPKTCSP KQFACRDQIT CISKGWRCDG ERDCPDGSDE 60
APEICPQSKA QRCPPNEHSC LGTELCVPMS RLCNGIQDCM DGSDEGAHCR ELRVNCSRMG 120
CQHHCVPTPS GPTCYCNNSF QLQADGKTCK DFDECSVYGT CSQLCTNTDG SFTCGCVEGY 180
LLQPDNRSCK AKNEPVDRPP VLLIANSQNI LATYLSGAQV STITPTSTRQ TTAMDFSYAN 240
ETVCWVHVGD SAAQTQLKCA RMPSLKGFVD EHTINISLSL HHVEQMAIDW LTGNFYFVDD 300
IDDRIFVCNR NGDTCVTLLD LELYNPKGIA LDPAMGKVFF TDYGQIPKVE RCDMDGQNRT 360
KLVDSKIVFP HGITLDLVSR LVYWADAYLD YIEVVDYEGK GRQTIIQGIL IEHLYGLTVF 420
ENYLYATNSD NANTQQKTSV IRVNRFNSTE YQVVTRVDKG GALHIYHQRR QPRVRSHACE 480
NDQYGKPGGC SDICLLANSH KARTCRCRSG FSLGSDGKSC KKPEHELFLV YGKGRPGIIR 540
GMDMGAKVPD EHMIPIENLM NPRALDFHAE TGFIYFADTT SYLIGRQKID GTERETILKD 600
GIHNVEGVAV DWMGDNLYWT DDGPKKTISV ARLEKAAQTR KTLIEGKMTH PRAIVVDPLN 660
GWMYWTDWEE DPKDSRRGRL ERAWMDGSHR DIFVTSKTVL WPNGLSLDIP AGRLYWVDAF 720
YDRIETILLN GTDRKIVYEG PELNHAFGLC HHGNYLFWTE YRSGSVYRLE RGVAGAQPTV 780
TLLRSERPPI FEIRMYDAQQ QQVGTNKCRV NNGGCSSLCL ATPGSRQCAC AEDQVLDADG 840
VTCLANPSYV PPPQCQPGEF ACANNRCIQE RWKCDGDNDC LDNSDEAPAL CHQHTCPSDR 900
FKCENNRCIP NRWLCDGDND CGNSEDESNA TCSARTCPPN QFSCASGRCI PISWTCDLDD 960
DCGDRSDESA SCAYPTCFPL TQFTCNNGRC ININWRCDND NDCGDNSDEA GCSHSCSSTQ 1020
FKCNSGRCIP EHWTCDGDND CGDYSDETHA NCTNQATRPP GGCHSDEFQC RLDGLCIPLR 1080
WRCDGDTDCM DSSDEKGCEG VTHVCDPNVK FGCKDSARCI SKAWVCDGDS DCEDNSDEEN 1140
CEALACRPPS HPCANNTSVC LSPDKLCDGK DDCGDGSDEG ELCDQCSLNN GGCSHNCSVA 1200
PGEGIVCSCP LGMELGPDNH TCQIQSYCAK HLKCSQKCDQ NKFSVKCSCY EGWVLEPDGE 1260
SCRSLDPFKP FIIFSNRHEI RRIDLHKGDY SVLVPGLRNT IALDFHLSQS ALYWTDVVED 1320
KIYRGKLLDN GALTSFEVVI QYGLATPEGL AVDWIAGNIY WVESNLDQIE VAKLDGTLRT 1380
TLLAGDIEHP RAIALDPRDG ILFWTDWDAS LPRIEAASMS GAGRRTIHRE TGSGGWPNGL 1440
TVDYLEKRIL WIDARSDAIY SARYDGSGHM EVLRGHEFLS HPFAVTLYGG EVYWTDWRTN 1500
TLAKANKWTG HNVTVVQRTN TQPFDLQVYH PSRQPMAPNP CEANGGRGPC SHLCLINYNR 1560
TVSCACPHLM KLHNDNTTCY EFKKFLLYAR QMEIRGVDLD APYYNYIISF TVPDIDNVTV 1620
LDYDAREQRV YWSDVRTQAI KRAFINGTGV ETVVSADLPN AHGLAVDWVS RNLFWTSYDT 1680
NKKQINVARL DGSFKNAVVQ GLEQPHGLVV HPLRGKLYWT DGDNISMVNM DGSNRTLLFS 1740
GQKGPVGLAI DFPESKLYWI SSGNHTINRC NLDGSELEVI DTMRSQLGKA TALAIMGDKL 1800
WWADQVSEKM GTCNKADGSG SVVLRNSTTL VMHMKVYDES IQLEHEGTNP CSVNNGDCSQ 1860
LCLPTSETTR SCMCTAGYSL RSGQQACEGV GSFLLYSVHE GIRGIPLDPN DKSDALVPVS 1920
GTSLAVGIDF HAENDTIYWV DMGLSTISRA KRDQTWREDV VTNGIGRVEG IAVDWIAGNI 1980
YWTDQGFDVI EVARLNGSFR YVVISQGLDK PRAITVHPEK GYLFWTEWGH YPRIERSRLD 2040
GTERVVLVNV SISWPNGISV DYQGGKLYWC DARMDKIERI DLETGENREV VLSSNNMDMF 2100
SVSVFEDFIY WSDRTHANGS IKRGCKDNAT DSVPLRTGIG VQLKDIKVFN RDRQKGTNVC 2160
AVANGGCQQL CLYRGGGQRA CACAHGMLAE DGASCREYAG YLLYSERTIL KSIHLSDERN 2220
LNAPVQPFED PEHMKNVIAL AFDYRAGTSP GTPNRIFFSD IHFGNIQQIN DDGSGRTTIV 2280
ENVGSVEGLA YHRGWDTLYW TSYTTSTITR HTVDQTRPGA FERETVITMS GDDHPRAFVL 2340
DECQNLMFWT NWNELHPSIM RAALSGANVL TLIEKDIRTP NGLAIDHRAE KLYFSDATLD 2400
KIERCEYDGS HRYVILKSEP VHPFGLAVYG EHIFWTDWVR RAVQRANKYV GSDMKLLRVD 2460
IPQQPMGIIA VANDTNSCEL SPCRINNGGC QDLCLLTHQG HVNCSCRGGR ILQEDFTCRA 2520
MNSSCRAQDE FECANGECIS FSLTCDGVSH CKDKSDEKPS YCNSRRCKKT FRQCNNGRCV 2580
SNMLWCNGVD DCGDGSDEIP CNKTACGVGE FRCRDGSCIG NSSRCNQFVD CEDASDEMNC 2640
SATDCSSYFR LGVKGVLFQP CERTSLCYAP SWVCDGANDC GDYSDERDCP GVKRPRCPLN 2700
YFACPSGRCI PMSWTCDKED DCENGEDETH CNKFCSEAQF ECQNHRCISK QWLCDGSDDC 2760
GDGSDEAAHC EGKTCGPSSF SCPGTHVCVP ERWLCDGDKD CADGADESIS AGCLYNSTCD 2820
DREFMCQNRL CIPKHFVCDH DRDCADGSDE SPECEYPTCG PNEFRCANGR CLSSRQWECD 2880
GENDCHDHSD EAPKNPHCTS PEHKCNASSQ FLCSSGRCVA EALLCNGQDD CGDGSDERGC 2940
HVNECLSRKL SGCSQDCEDL KIGFKCRCRP GFRLKDDGRT CADVDECSTT FPCSQLCINT 3000
HGSYKCLCVE GYAPRGGDPH SCKAVTDEEP FLIFANRYYL RKLNLDGSNY TLLKQGLNNA 3060
VALDFDYRGQ MIYWTDVTTQ GSMIRRMHLN GSNVQVLHRT GLSNPDGLAV DWVGGNLYWC 3120
DKGRDTIEVS KLNGAYRTVL VSSGLREPRA LVVDVQNGYL YWTDWGDHSL IGRIGMDGSG 3180
RSIIVDTKIT WPNGLTVDYV TERIYWADAR EDYIEFASLD GSNRHVVLSQ DIPHIFALTL 3240
FEDYVYWTDW ETKSINRAHK TTGANKTLLI STLHRPMDLH VFHALRQPDV PNHPCKVNNG 3300
GCSNLCLLSP GGGHKCACPT NFYLGGDGRT CVSNCTASQF VCKNDKCIPF WWKCDTEDDC 3360
GDHSDEPPDC PEFKCRPGQF QCSTGICTNP AFICDGDNDC QDNSDEANCD IHVCLPSQFK 3420
CTNTNRCIPG IFRCNGQDNC GDGEDERDCP EVTCAPNQFQ CSITKRCIPR VWVCDRDNDC 3480
VDGSDEPANC TQMTCGVDEF RCKDSGRCIP ARWKCDGEDD CGDGSDEPKE ECDERTCEPY 3540
QFRCKNNRCV PGRWQCDYDN DCGDNSDEES CTPRPCSESE FSCANGRCIA GRWKCDGDHD 3600
CADGSDEKDC TPRCDMDQFQ CKSGHCIPLR WRCDADADCM DGSDEEACGT GVRTCPLDEF 3660
QCNNTLCKPL AWKCDGEDDC GDNSDENPEE CTRFQCPPNR PFRCKNDRVC LWIGRQCDGT 3720
DNCGDGTDEE DCEPPTAQNP HCKDKKEFLC RNQRCLSSSL RCNMFDDCGD GSDEEDCSID 3780
PKLTSCATNA SMCGDEARCV RTEKAAYCAC RPGFHTVPGQ PGCQDINECL RFGTCSQLCN 3840
NTKGGHLCSC ARNFMKTHNT CKAEGSEYQV LYIADDNEIR SLFPGHPHSA YEQAFQGDES 3900
VRIDAMDVHV KAGRVYWTNW HTGTISYRSL PPAAPPTTSN RHRRQIDRGV THLNISGLKM 3960
PRGIAIDWVA GNVYWTDSGR DVIEVAQMKG ENRKTLISGM IDEPHAIVVD PLRGTMYWSD 4020
WGNHPKIETA AMDGTLRETL VQDNIQWPTG LAVDYHNERL YWADAKLSVI GSIRLNGTDP 4080
IVAVDSKRGL SHPFSIDVFE DYIYGVTYIN NRVFKIHKFG HSPLINLTGG LSHASDVVLY 4140
HQHKQPEVTN PCDRKKCEWL CLLSPSGPVC TCPNGKRLDN GTCVPVPSPT PPPDAPRPGT 4200
CTLQCFNGGS CFLNARRQPK CRCQPRYTGD KCELDQCWEY CHNGGTCAAS PSGMPTCRCP 4260
TGFTGPRCTQ QVCAGYCANN STCTVNQGNQ PQCRCLPGFL GDRCQYRQCS GFCENFGTCQ 4320
MAADGSRQCR CTVYFEGTRC EVNKCSRCLQ GACVVNKQTG DVTCNCTDGR VAPSCLTCID 4380
HCSNGGSCTM NSKMMPECQC PPHMTGPRCE EQVVSQQQPG HMTSILIPLL LLLLLLLVAG 4440
VVFWYKRRVR GAKGFQHQRM TNGAMNVEIG NPTYKMYEGG EPDDVGGLLD ADFALDPDKP 4500
TNFTNPVYAT LYMGGHGSRH SLASTDEKRE LLGRGPEDEI GDPLA 4545 
Gene Ontology
 GO:0030136; C:clathrin-coated vesicle; IDA:RGD.
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0005768; C:endosome; IDA:RGD.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0007568; P:aging; IEP:RGD.
 GO:0035909; P:aorta morphogenesis; IEA:Compara.
 GO:0043277; P:apoptotic cell clearance; IEA:Compara.
 GO:0097242; P:beta-amyloid clearance; IEA:Compara.
 GO:0008283; P:cell proliferation; IMP:RGD.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0042157; P:lipoprotein metabolic process; IEP:RGD.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.
 GO:2000587; P:negative regulation of platelet-derived growth factor receptor-beta signaling pathway; IEA:Compara.
 GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Compara.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IEA:Compara.
 GO:0010875; P:positive regulation of cholesterol efflux; IEA:Compara.
 GO:0051222; P:positive regulation of protein transport; IMP:RGD.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IMP:RGD.
 GO:0006898; P:receptor-mediated endocytosis; IMP:RGD.
 GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Compara.
 GO:0032429; P:regulation of phospholipase A2 activity; IEA:Compara. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR026823; cEGF.
 IPR006150; Cys_repeat_1.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR023415; LDLR_class-A_CS.
 IPR000033; LDLR_classB_rpt.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF12662; cEGF
 PF07645; EGF_CA
 PF00057; Ldl_recept_a
 PF00058; Ldl_recept_b 
SMART
 SM00181; EGF
 SM00179; EGF_CA
 SM00192; LDLa
 SM00135; LY
 SM00289; WR1 
PROSITE
 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS51120; LDLRB 
PRINTS