CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000909
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trafficking kinesin-binding protein 2 
Protein Synonyms/Alias
 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein 
Gene Name
 TRAK2 
Gene Synonyms/Alias
 ALS2CR3; KIAA0549 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
107DRVEQMTKTYNDIDMubiquitination[1]
138RIGQALLKRNHVLSEubiquitination[1]
273MTEELSGKSDELIRYubiquitination[1]
299VDLQHKLKEHVIEKEacetylation[2]
299VDLQHKLKEHVIEKEubiquitination[1]
385IEGTMRKKLSLDEESubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR (By similarity). 
Sequence Annotation
 DOMAIN 48 353 HAP1 N-terminal.
 REGION 359 509 Interaction with HGS (By similarity).  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Endosome; Glycoprotein; Mitochondrion; Polymorphism; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 914 AA 
Protein Sequence
MSQSQNAIFT SPTGEENLMN SNHRDSESIT DVCSNEDLPE VELVSLLEEQ LPQYRLKVDT 60
LFLYENQDWT QSPHQRQHAS DALSPVLAEE TFRYMILGTD RVEQMTKTYN DIDMVTHLLA 120
ERDRDLELAA RIGQALLKRN HVLSEQNESL EEQLGQAFDQ VNQLQHELCK KDELLRIVSI 180
ASEESETDSS CSTPLRFNES FSLSQGLLQL EMLQEKLKEL EEENMALRSK ACHIKTETVT 240
YEEKEQQLVS DCVKELRETN AQMSRMTEEL SGKSDELIRY QEELSSLLSQ IVDLQHKLKE 300
HVIEKEELKL HLQASKDAQR QLTMELHELQ DRNMECLGML HESQEEIKEL RSRSGPTAHL 360
YFSQSYGAFT GESLAAEIEG TMRKKLSLDE ESSLFKQKAQ QKRVFDTVRI ANDTRGRSIS 420
FPALLPIPGS NRSSVIMTAK PFESGLQQTE DKSLLNQGSS SEEVAGSSQK MGQPGPSGDS 480
DLATALHRLS LRRQNYLSEK QFFAEEWQRK IQVLADQKEG VSGCVTPTES LASLCTTQSE 540
ITDLSSASCL RGFMPEKLQI VKPLEGSQTL YHWQQLAQPN LGTILDPRPG VITKGFTQLP 600
GDAIYHISDL EEDEEEGITF QVQQPLEVEE KLSTSKPVTG IFLPPITSAG GPVTVATANP 660
GKCLSCTNST FTFTTCRILH PSDITQVTPS SGFPSLSCGS SGSSSSNTAV NSPALSYRLS 720
IGESITNRRD STTTFSSTMS LAKLLQERGI SAKVYHSPIS ENPLQPLPKS LAIPSTPPNS 780
PSHSPCPSPL PFEPRVHLSE NFLASRPAET FLQEMYGLRP SRNPPDVGQL KMNLVDRLKR 840
LGIARVVKNP GAQENGRCQE AEIGPQKPDS AVYLNSGSSL LGGLRRNQSL PVIMGSFAAP 900
VCTSSPKMGV LKED 914 
Gene Ontology
 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0050811; F:GABA receptor binding; NAS:HGNC.
 GO:0006493; P:protein O-linked glycosylation; IEA:Compara.
 GO:0006605; P:protein targeting; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR006933; HAP1_N.
 IPR022154; Traffickng_kinesin-bd_prot_dom. 
Pfam
 PF04849; HAP1_N
 PF12448; Milton 
SMART
  
PROSITE
  
PRINTS