Tag | Content |
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CPLM ID | CPLM-002684 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | C4b-binding protein |
Protein Synonyms/Alias | C4bp |
Gene Name | C4bpa |
Gene Synonyms/Alias | C4bp |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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165 | SSCEVRGKGVAWSNP | ubiquitination | [1] | 331 | LVTYECDKGYRLVGK | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component. |
Sequence Annotation | DOMAIN 57 117 Sushi 1. DOMAIN 118 178 Sushi 2. DOMAIN 179 242 Sushi 3. DOMAIN 243 301 Sushi 4. DOMAIN 302 357 Sushi 5. DOMAIN 358 415 Sushi 6. CARBOHYD 74 74 N-linked (GlcNAc...) (Potential). CARBOHYD 227 227 N-linked (GlcNAc...) (Potential). CARBOHYD 275 275 N-linked (GlcNAc...). CARBOHYD 292 292 N-linked (GlcNAc...) (Potential). CARBOHYD 366 366 N-linked (GlcNAc...) (Potential). CARBOHYD 381 381 N-linked (GlcNAc...) (Potential). CARBOHYD 428 428 N-linked (GlcNAc...) (Potential). DISULFID 58 103 By similarity. DISULFID 88 115 By similarity. DISULFID 120 160 By similarity. DISULFID 146 176 By similarity. DISULFID 181 223 By similarity. DISULFID 209 240 By similarity. DISULFID 245 287 By similarity. DISULFID 273 299 By similarity. DISULFID 303 343 By similarity. DISULFID 329 355 By similarity. DISULFID 359 400 By similarity. DISULFID 386 413 By similarity. |
Keyword | Complement pathway; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Innate immunity; Reference proteome; Repeat; Secreted; Signal; Sushi. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 469 AA |
Protein Sequence | MCAKQQQTLL PTRAAHGRLH RNRDAVAWPF STLCRVSGPT LFQMTFTAAL WVAVFGKCGP 60 PPAIPNALPA SDVNRTDFES HTTLKYECLP GYGRGISRMM VYCKPSGEWE ISVSCAKKHC 120 RNPGYLDNGY VNGETITFGS QIEFSCQEGF ILVGSSTSSC EVRGKGVAWS NPFPECVIVK 180 CGPPPDISNG KHSGTEDFYP YNHGISYTCD PGFRLVGSPF IGCTVVNKTV PVWSSSPPTC 240 EKIICSQPNI LHGVIVSGYK ATYTHRDSVR LACLNGTVLR GRHVIECQGN GNWSSLPTCE 300 FDCDLPPAIV NGYYTSMVYS KITLVTYECD KGYRLVGKAI ISCSFSKWKG TAPQCKALCQ 360 KPEVGNGTLS DEKDQYVESE NVTIQCDSGF AMLGSQSISC SESGTWYPEV PRCEQEASED 420 LKPALTGNKT MQYVPNSHDV KMALEIYKLT LEVELLQLQI QKEKHTEAH 469 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW. GO:0045087; P:innate immune response; IEA:UniProtKB-KW. |
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Pfam | |
SMART | |
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PRINTS | |