UniProt Accession

 CDK5_DROME; P48609; Q94878; Q9V7D8 

Genbank Protein ID

 U21552; X99511; AE013599; AY061049 

Genbank Nucleotide ID

 AAA63754.1; CAA67861.1; AAF58119.1; AAL28597.1 

Protein Name

 Cyclin-dependent kinase 5 homolog 

Protein Synonyms/Alias

 Cell division protein kinase 5 

Gene Name

 Cdk5 

Gene Synonyms/Alias

 CG8203 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
56	LREICLLKELKHKNI	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Possible regulator of neuronal differentiation and/or development (By similarity). 

Sequence Annotation

 DOMAIN 4 286 Protein kinase.
 NP_BIND 10 18 ATP (By similarity).
 ACT_SITE 126 126 Proton acceptor (By similarity).
 BINDING 33 33 ATP (By similarity).
 MOD_RES 14 14 Phosphothreonine (By similarity).
 MOD_RES 15 15 Phosphotyrosine (By similarity).
 MOD_RES 159 159 Phosphoserine (By similarity).  

Keyword

 ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0016533; C:cyclin-dependent protein kinase 5 holoenzyme complex; IPI:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IDA:FlyBase.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
 GO:0007629; P:flight behavior; IMP:FlyBase.
 GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IGI:FlyBase.
 GO:0035011; P:melanotic encapsulation of foreign target; IMP:FlyBase.
 GO:0008045; P:motor neuron axon guidance; IMP:FlyBase.
 GO:0008582; P:regulation of synaptic growth at neuromuscular junction; IMP:FlyBase. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS