UniProt Accession

 THRSP_MOUSE; Q62264 

Genbank Protein ID

 X95279; BC009165 

Genbank Nucleotide ID

 CAA64600.1; AAH09165.1 

Protein Name

 Thyroid hormone-inducible hepatic protein 

Protein Synonyms/Alias

 Spot 14 protein; S14; SPOT14 

Gene Name

 Thrsp 

Gene Synonyms/Alias

 S14 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
10	VLTKRYPKNCLLTVM	ubiquitination	[1]
83	PREEWQAKVAGNETS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Lipid biosynthesis; Lipid metabolism; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 150 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0010866; P:regulation of triglyceride biosynthetic process; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009786; Spot_14. 

Pfam

 PF07084; Spot_14 

SMART

  

PROSITE

  

PRINTS