UniProt Accession

 THIE_ECOLI; P30137; Q2M8T0 

Genbank Protein ID

 M88701; U00006; U00096; AP009048 

Genbank Nucleotide ID

 AAB95617.1; AAC43091.1; AAC76967.1; BAE77326.1 

Protein Name

 Thiamine-phosphate synthase 

Protein Synonyms/Alias

 TP synthase; TPS; Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase 

Gene Name

 thiE 

Gene Synonyms/Alias

 b3993; JW3957 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
137	HVFPTQTKQMPSAPQ	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). 

Sequence Annotation

 REGION 37 41 HMP-PP binding (By similarity).
 REGION 134 136 THZ-P binding (By similarity).
 REGION 186 187 THZ-P binding (By similarity).
 METAL 70 70 Magnesium (By similarity).
 METAL 89 89 Magnesium (By similarity).
 BINDING 69 69 HMP-PP (By similarity).
 BINDING 108 108 HMP-PP (By similarity).
 BINDING 137 137 HMP-PP (By similarity).
 BINDING 166 166 THZ-P; via amide nitrogen (By  

Keyword

 Complete proteome; Magnesium; Metal-binding; Reference proteome; Thiamine biosynthesis; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 211 AA 

Protein Sequence

Gene Ontology

 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0004789; F:thiamine-phosphate diphosphorylase activity; IEA:HAMAP.
 GO:0009228; P:thiamine biosynthetic process; IEA:HAMAP.
 GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR022998; ThiaminP_synth_SF.
 IPR003733; TMP_synthase. 

Pfam

 PF02581; TMP-TENI 

SMART

  

PROSITE

  

PRINTS