UniProt Accession

 NSE4A_HUMAN; Q9NXX6; Q5SQQ5; Q6P673; Q8WY66; Q9BS90 

Genbank Protein ID

 AK000010; AK222487; AL731566; AL731566; BC005212; BC062427; AF258584 

Genbank Nucleotide ID

 BAA90881.1; BAD96207.1; CAI14816.1; CAI14817.1; AAH05212.1; AAH62427.1; AAG23787.1 

Protein Name

 Non-structural maintenance of chromosomes element 4 homolog A 

Protein Synonyms/Alias

 NS4EA; Non-SMC element 4 homolog A 

Gene Name

 NSMCE4A 

Gene Synonyms/Alias

 C10orf86; PP4762 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
147	ASDLGKEKAKQLRSD	ubiquitination	[1]
238	PRVDRPRKVPVIQEE	ubiquitination	[1, 2]
265	SHQEATEKEVERILG	ubiquitination	[1, 2]
365	RDWEEIVKTFEISEP	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. 

Sequence Annotation

 MOD_RES 345 345 Phosphothreonine.
 MOD_RES 377 377 Phosphoserine.  

Keyword

 Alternative splicing; Chromosome; Complete proteome; DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Telomere. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 385 AA 

Protein Sequence

Gene Ontology

 GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030915; C:Smc5-Smc6 complex; IDA:UniProtKB.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:2001022; P:positive regulation of response to DNA damage stimulus; IMP:UniProtKB. 

Interpro

 IPR014854; Nse4. 

Pfam

 PF08743; Nse4 

SMART

  

PROSITE

  

PRINTS