UniProt Accession

 GATA4_HUMAN; P43694; B7ZKX0; Q3MJ45; Q5IFM8 

Genbank Protein ID

 L34357; AY740706; BC101580; BC105108; BC143434 

Genbank Nucleotide ID

 AAA58496.1; AAW51922.1; AAI01581.1; AAI05109.1; AAI43435.1 

Protein Name

 Transcription factor GATA-4 

Protein Synonyms/Alias

 GATA-binding factor 4 

Gene Name

 GATA4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
312	PRPLAMRKEGIQTRK	acetylation	[1]
319	KEGIQTRKRKPKNLN	acetylation	[1]
321	GIQTRKRKPKNLNKS	acetylation	[1]
323	QTRKRKPKNLNKSKT	acetylation	[1]
365	SEEMRPIKTEPGLSS	sumoylation	[2]

Reference

 [1] Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes.
 Takaya T, Kawamura T, Morimoto T, Ono K, Kita T, Shimatsu A, Hasegawa K.
 J Biol Chem. 2008 Apr 11;283(15):9828-35. [PMID: 18252717]
 [2] SUMO-1 modification activated GATA4-dependent cardiogenic gene activity.
 Wang J, Feng XH, Schwartz RJ.
 J Biol Chem. 2004 Nov 19;279(47):49091-8. [PMID: 15337742] 

Functional Description

 Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement. 

Sequence Annotation

 ZN_FING 217 241 GATA-type 1.
 ZN_FING 271 295 GATA-type 2.
 MOD_RES 300 300 N6-methyllysine; by EZH2 (By similarity).  

Keyword

 Activator; Atrial septal defect; Cardiomyopathy; Complete proteome; Disease mutation; DNA-binding; Metal-binding; Methylation; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 442 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0033613; F:activating transcription factor binding; ISS:BHF-UCL.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IEA:Compara.
 GO:0001076; F:RNA polymerase II transcription factor binding transcription factor activity; IDA:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; ISS:BHF-UCL.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0003289; P:atrial septum primum morphogenesis; ISS:BHF-UCL.
 GO:0003290; P:atrial septum secundum morphogenesis; IMP:BHF-UCL.
 GO:0003181; P:atrioventricular valve morphogenesis; IEA:Compara.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0003215; P:cardiac right ventricle morphogenesis; ISS:BHF-UCL.
 GO:0061049; P:cell growth involved in cardiac muscle cell development; IEA:Compara.
 GO:0007267; P:cell-cell signaling; ISS:BHF-UCL.
 GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Compara.
 GO:0071333; P:cellular response to glucose stimulus; IEA:Compara.
 GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Compara.
 GO:0048617; P:embryonic foregut morphogenesis; ISS:BHF-UCL.
 GO:0035054; P:embryonic heart tube anterior/posterior pattern specification; ISS:BHF-UCL.
 GO:0003197; P:endocardial cushion development; IMP:BHF-UCL.
 GO:0007492; P:endoderm development; TAS:BHF-UCL.
 GO:0001706; P:endoderm formation; IEA:Compara.
 GO:0072148; P:epithelial cell fate commitment; IEA:Compara.
 GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
 GO:0001947; P:heart looping; ISS:BHF-UCL.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0060575; P:intestinal epithelial cell differentiation; IDA:MGI.
 GO:0060464; P:lung lobe formation; IEA:Compara.
 GO:0008584; P:male gonad development; IEP:UniProtKB.
 GO:0010507; P:negative regulation of autophagy; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; ISS:BHF-UCL.
 GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Compara.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Compara.
 GO:0051891; P:positive regulation of cardioblast differentiation; ISS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0010575; P:positive regulation vascular endothelial growth factor production; ISS:BHF-UCL.
 GO:0042493; P:response to drug; IMP:BHF-UCL.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0072520; P:seminiferous tubule development; IEA:Compara.
 GO:0060008; P:Sertoli cell differentiation; IEA:Compara.
 GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Compara.
 GO:0060395; P:SMAD protein signal transduction; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0003229; P:ventricular cardiac muscle tissue development; IEA:Compara.
 GO:0003281; P:ventricular septum development; ISS:BHF-UCL. 

Interpro

 IPR008013; GATA_N.
 IPR016375; TF_GATA_4/5/6.
 IPR000679; Znf_GATA.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00320; GATA
 PF05349; GATA-N 

SMART

 SM00401; ZnF_GATA 

PROSITE

 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2 

PRINTS

 PR00619; GATAZNFINGER.