CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017176
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5-oxoprolinase 
Protein Synonyms/Alias
 5-oxo-L-prolinase; 5-OPase; Pyroglutamase 
Gene Name
 Oplah 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
34GGHVRVLKLLSEDPAubiquitination[1]
154PGAGSPVKGCTGDLLubiquitination[1]
175DLAALRGKLEGLLTRubiquitination[1]
385PGPACYRKGGPVTVTubiquitination[1]
651LQLEETSKIQSGPPHubiquitination[1]
732APSMIDTKLDPIQLSubiquitination[1]
766TAISTNIKERLDFSCubiquitination[1]
906EALQAPGKISGCSGTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1288 AA 
Protein Sequence
MGSPEERFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYADAPTEG IRRILEQERG 60
VLLPRGRPLD TSHIASIRMG TTVATNALLE RQGERVALLV TRGFRDLLHI GTQARPDLFD 120
LAVPMPEVLY EEVVEVDERV LLYRGEPGAG SPVKGCTGDL LEIQQPVDLA ALRGKLEGLL 180
TRGIHSLAVV LMHSYTWAQH EQQVGTLARE LGFTHVSLSS EVMPMVRIVP RGHTACADAY 240
LTPTIQRYVQ GFRRGFQGQL KNVQVLFMRS DGGLAPMDAF SGSRAVLSGP AGGVVGYSTT 300
TYQLEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN TVAAGGGSRL 360
FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR LLPASFPCIF GPGEDQPLSP 420
EASRKALEAV AMEVNSFLAS GPCPASQLSL EEVAMGFVRV ANEAMCRPIR ALTQARGHDP 480
SAHVLACFGG AGGQHACAIA RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLSYT 540
PETFAQLDQR LSRLEEQCVD ALQAQGFSRS QISTESFLHL RYQGTDCALM VSANQHPATT 600
CSPRAGDFGA AFVERYMREF GFIIPERSVV VDDVRVRGTG RSGLQLEETS KIQSGPPHVE 660
KVTQCYFEGG YQETPVYLLG ELGYGHQLQG PCLIIDNNST ILVEPGCQAE VIETGDIRIS 720
VGAEAPSMID TKLDPIQLSI FSHRFMSIAE QMGRILQRTA ISTNIKERLD FSCALFGPDG 780
GLVSNAPHIP VHLGAMQETV QFQIQHLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW 840
PGQSRPVFYV ASRGHHADIG GITPGSMPPH STTLQQEGAV FLSFKLVQGG VFQEEAVTEA 900
LQAPGKISGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ AYMGHIQANA 960
ELAVRDMLRA FGTSRQARGL PLEVSAKDHM DDGSPICLHV QINLNQGSAV FDFSGSGSEV 1020
FGNLNAPRAI TLSALIYCLR CLVGRDIPLN QGCLAPVQVI IPKGSILDPS PEAAVVGGNV 1080
LTSQRVVDVI LGAFGACAAS QGCMNNVTLG NARMGYYETV AGGAGAGPGW HGRSGVHSHM 1140
TNTRITDPEI LESRYPVILR RFELRPGSGG RGRFRGGDGV VRELVFREEA LLSVLTERRA 1200
FQPYGLHGGE PGTRGLNLLI RKDGRTVNLG GKTSVTVYPG DAFCLHTPGG GGYGDPEDPA 1260
PPPGSPPLYP AFPERGSVYE YRRAQEAV 1288 
Gene Ontology
 GO:0017168; F:5-oxoprolinase (ATP-hydrolyzing) activity; ISS:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006749; P:glutathione metabolic process; ISS:MGI. 
Interpro
 IPR008040; Hydant_A_N.
 IPR002821; Hydantoinase_A.
 IPR003692; Hydantoinase_B. 
Pfam
 PF05378; Hydant_A_N
 PF01968; Hydantoinase_A
 PF02538; Hydantoinase_B 
SMART
  
PROSITE
  
PRINTS